(A) Incidence of UK EMRSA-15 every 4 weeks (red crosses) and cumulative cases (blue curve). (B) The raster plot for infections in 114 infected wards. Color indicates number of observed infections …
Numerical data represented in Figure 1.
The data set includes: (1) incidence data in Figure 1A; (2) ward number, infection number, total visit, average stay and ward capacity visualized in Figure 1B–C.
(A) Number of wards with a given number of total patient-days in the hospitalization records. Inset shows the scatter plot of the number of positive cases and patient-days per ward. (B) Average …
(A) Daily patient overlap ratio Q during 300 days. Inset provides a zoom-in plot of the first 30 days. (B) The number of total patients and new patients (with respect to patients present the …
(A) Distributions of the posterior parameters (top), (middle) and (bottom) (300 ensemble members) for 20 iterations of inference in one realization of the IF algorithm. Orange Tukey boxes …
Numerical data represented in Figure 2.
The data set includes: (1) distributions of , and in Figure 2A; (2) distributions of inferred incidence and actual observation in the synthetic outbreak in Figure 2B; (3) distributions of inferred colonization and actual colonization in the synthetic outbreak in Figure 2C; (4) distributions of inferred transmitted incidence and actual transmitted incidence in the synthetic outbreak in Figure 2D; (5) distributions of inferred imported incidence and actual imported incidence in the synthetic outbreak in Figure 2E.
(A) Distribution of the log likelihood calculated from surrogate data (blue bars). We generated 1000 synthetic outbreaks using the inferred parameters, from which we approximated the distribution of …
(A) Parameters used in the synthetic outbreak (inference targets) are marked by red lines. The posterior parameter distributions (300 ensemble members) for different iterations in one realization of …
Same analysis as in Figure 2—figure supplement 1. Comparisons of the log likelihood (A), RMSE (B), (C), and Pearson correlation coefficient (D) obtained from the inference in Figure 2—figure …
Parameters are set as in Figure 2. (A) Parameters used in the synthetic outbreak (inference targets) are marked by red lines. The posterior parameter distributions (300 ensemble members) for …
Same analysis as in Figure 2—figure supplement 1. Comparisons of the log likelihood (A), RMSE (B), (C), and Pearson correlation coefficient (D) obtained from the inference in Figure 2—figure …
(A) Inferred distributions of the MLEs for key parameters , and over 6 years, obtained from 100 independent realizations of the IF algorithm. (B) Observed incidence every 4 weeks (red …
Numerical data represented in Figure 3.
The data set includes: (1) distributions of inferred parameters in Figure 3A; (2) distributions of inferred incidence and actual observation in the real-world outbreak in Figure 3B; (3) distribution of the number of infected wards obtained from inference in Figure 3C; (4) observed and inferred distributions of the number of infections per ward in Figure 3D; (5) distributions of inferred nosocomial transmitted and imported cases in Figure 3E.
In each year, we performed 20 iterations using the IF. Boxes show the inferred distributions of 300 posterior parameters (box: interquartile; whisker: 95% CI).
We generated the surrogate data (1000 synthetic outbreaks) using the inferred parameters, and compared the log likelihood (A), RMSE (B), (C), and Pearson correlation coefficient (D) obtained from …
We classified the patients testing positive according to the time intervals between their hospital admission and confirmation date: those with days (48 hr) were regarded as imported cases (199 …
(A) Inferred distributions of colonized patients through time. (B) The distribution of colonization probability for each individual in hospital at T = 40 (week 160) calculated from 104 model …
Numerical data represented in Figure 4.
(B) Comparison of the KS statistic between synthetic samples and observed data. The vertical line indicates the KS statistic for the observed data.
The cumulative cases of colonization (A) and infection (B) after decolonizing patients with a hazard of colonization higher than a specified decolonization threshold. Simulations were performed with …
Numerical data represented in Figure 5.
The data set includes: (1) distributions of colonization for each decolonization threshold in Figure 5A; (2) distributions of infection for each decolonization threshold in Figure 5B; (3) colonization number for each control strategy in Figure 5C; (4) infection number for each control strategy in Figure 5D.
We visualize a single realization of the agent-based model during a one-year period. The grey nodes represent susceptible people, green nodes represent colonized individuals, and red nodes highlight …
Parameter | Description | Range | Unit |
---|---|---|---|
Spontaneous decolonization rate | [1/525, 1/175] | per day | |
Infection progress rate | [0.1, 0.3] | per day | |
Recovery rate with treatment | [1/120, 1/20] | per day | |
Transmission rate in hospitals | [0, 0.01] | per day | |
Infection importation rate | [0, 0.001] | per admission | |
Colonization importation rate | [0, 0.1] | per admission | |
Sources for parameter ranges – : (Cooper et al., 2004a; Bootsma et al., 2006; Eveillard et al., 2006; Wang et al., 2013; Macal et al., 2014; Jarynowski and Liljeros, 2015); : (Kajita et al., 2007; Jarynowski and Liljeros, 2015); : (D'Agata et al., 2009; Wang et al., 2013); : Prior; : Prior; : Prior, (Hidron et al., 2005; Eveillard et al., 2006; Jarvis et al., 2012). For each individual, the infection progress rate is drawn after is specified.
Inferred parameters and 95% CIs | |||
---|---|---|---|
Year | |||
I | |||
II | |||
III | |||
IV | |||
V | |||
VI | |||
Numerical data represented in Table 2.
Results are obtained from 100 independent realizations of the IF algorithm.
Actual | |||
---|---|---|---|
Inference (weekly) | |||
Actual | |||
Inference (weekly) | |||
Actual | |||
Inference (monthly) |
The Matlab code for parameter inference in a synthetic MRSA outbreak simulated in an example time-varying contact network.