Simulated trajectories (mean ±95% confidence intervals) are shown for two different Y-shredding efficiencies (PY), assuming the drive was positioned within a non-coding (a, b) or coding region (c, d). Total population and allosome genotype trajectories (i), and the proportion of different autosome genotypes (ii), are shown for each scenario. In the bottom right panel, all simulated populations were eradicated within 8 years. All simulations assumed an initial population size of 10,000 mice, inoculation with 100 gene-drive carrying XX females, polygynous breeding (Fmax = 3), and substantial opportunity for the creation of resistant alleles through non-homologous end-joining (PN = 0.1). In (c,d), the gene drive is assumed to be positioned within a haploinsufficient critical gene, such that resistance alleles cause early embryonic lethality (Pnf = 1). Abbreviations denoting different autosome alleles are: W, wildtype; G, gene drive, R, resistant.