Anterior insular cortex plays a critical role in interoceptive attention
Abstract
Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention, which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that AIC plays a critical role in interoceptive attention.
Data availability
Source data have been deposited in Dyrad, including behavioral data, fMRI data, and lesion patient data. Our Dyrad DOI is: doi:10.5061/dryad.5sj852c
-
Data from: Anterior insular cortex plays a critical role in interoceptive attentionDryad Digital Repository, doi 10.5061/dryad.5sj852c.
Article and author information
Author details
Funding
National Natural Science Foundation of China (81729001)
- Jin Fan
China Postdoctoral Science Foundation (2016M600835)
- Qiong Wu
National Institute on Drug Abuse (1R01DA043695)
- Xiaosi Gu
National Natural Science Foundation of China (81328008)
- Jin Fan
National Natural Science Foundation of China (61690205)
- Yanhong Wu
National Institute of Mental Health (R01MH094305)
- Jin Fan
Research grant of 973 (973-2015CB351800)
- Yanhong Wu
National Natural Science Foundation of China (31771205)
- Yanhong Wu
National Institute on Drug Abuse (Intramul Research Program)
- Yihong Yang
Brain research Project of Beijing (Z16110002616014)
- Pinan Liu
Beijing Municipal Administration of Hospital Youth programs (QML20170503)
- Xingchao Wang
National Natural Science Foundation of China (81600931)
- Xingchao Wang
Capital Health Development Research Project of Beijing (2016-4-1074)
- Xingchao Wang
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: All participants in fMRI study and in lesion study were gave written informed consent in accordance with the procedures and protocols approved by The Human Subjects Review Committee of Peking University and by The Institutional Review Board of the Beijing Tiantan Hospital, Capital Medical University, respectively.
Copyright
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Metrics
-
- 13,595
- views
-
- 1,078
- downloads
-
- 106
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Further reading
-
- Neuroscience
Aphantasia refers to reduced or absent visual imagery. While most of us can readily recall decade-old personal experiences (autobiographical memories, AM) with vivid mental images, there is a dearth of information about whether the loss of visual imagery in aphantasics affects their AM retrieval. The hippocampus is thought to be a crucial hub in a brain-wide network underlying AM. One important question is whether this network, especially the connectivity of the hippocampus, is altered in aphantasia. In the current study, we tested 14 congenital aphantasics and 16 demographically matched controls in an AM fMRI task to investigate how key brain regions (i.e. hippocampus and visual-perceptual cortices) interact with each other during AM re-experiencing. All participants were interviewed regarding their autobiographical memory to examine their episodic and semantic recall of specific events. Aphantasics reported more difficulties in recalling AM, were less confident about their memories, and described less internal and emotional details than controls. Neurally, aphantasics displayed decreased hippocampal and increased visual-perceptual cortex activation during AM retrieval compared to controls. In addition, controls showed strong negative functional connectivity between the hippocampus and the visual cortex during AM and resting-state functional connectivity between these two brain structures predicted better visualization skills. Our results indicate that visual mental imagery plays an important role in detail-rich vivid AM, and that this type of cognitive function is supported by the functional connection between the hippocampus and the visual-perceptual cortex.
-
- Neuroscience
- Stem Cells and Regenerative Medicine
A tailored cocktail of genes can reprogram a subset of progenitors to no longer produce glial cells and instead develop into neurons involved in motor control.