A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval
- Rotman Research Institute, Baycrest, Canada
- University of Toronto, Canada
- Northwestern University Feinberg School of Medicine, United States
Figures
Figure 1
Autobiographical memory paradigm.
Participants were cued with familiar words (locations, people, objects), and told to recall a past event in relation to this word. Construction was terminated when participants indicated they had an event in mind via button press.
Figure 2 with 1 supplement
Exploratory between-subjects analysis showing that precuneus stimulation leads to (A) reduced vividness ratings and (B) reduced ease of recall compared to vertex stimulation when considering only the first session for each participant.
Asterisks indicate a significant difference between precuneus and vertex stimulation (p<0.05).
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Figure 2—source data 1
Behavioural data.
File contains data for Figure 2. Behavioral data for precuneus and vertex stimulation sessions are included, and the counterbalancing order (first session) is indicated.
- https://doi.org/10.7554/eLife.43114.006
Figure 2—figure supplement 1
Exploratory between-subjects analysis showing non-significant differences between precuneus and vertex stimulation for (A) vividness and (B) ease of recall, when considering only the second session for each participant.
https://doi.org/10.7554/eLife.43114.005
Figure 3
Theta activity during autobiographical memory retrieval for vertex stimulation sessions.
(A) Theta power increases during AM retrieval relative to rest. (B) Increased theta phase coupling during AM retrieval using a right MTL seed (blue box). Theta power and phase coupling images displayed at p<0.005, cluster corrected. (C) Comodulogram showing theta-gamma phase-amplitude coupling between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines on comodulogram shows areas of significantly different phase-amplitude coupling between memory and rest. Comodulogram displayed at p<0.05, cluster corrected.
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Figure 3—source data 1
Data used for plotting comodulograms.
File contains data for panel C of Figure 3 (MTL-precuneus PAC), and data for non-significant mPFC and TPJ seeds.
- https://doi.org/10.7554/eLife.43114.009
Figure 4 with 1 supplement
Effects of cTBS on theta activity during memory elaboration relative to rest.
(A) Precuneus stimulation led to decreased theta phase coupling between a right MTL seed (blue box) and the left occipital lobe. Images displayed at p<0.005, cluster corrected. (B) Comodulograms showing theta-gamma phase-amplitude coupling separately for vertex (left) and precuneus (right) stimulation sessions, between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines show areas of significantly different phase-amplitude coupling between memory and rest. (C) Comparison between comodulograms in (B), showing precuneus compared to vertex stimulation during memory retrieval, between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines show areas of significantly different phase-amplitude coupling between precuneus and vertex stimulation. Comodulograms displayed at p<0.05, cluster corrected.
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Figure 4—source data 1
Data used for plotting comodulograms.
File contains data for panel C of Figure 4 (MTL-precuneus PAC), and data for non-significant mPFC and TPJ seeds.
- https://doi.org/10.7554/eLife.43114.012
Figure 4—figure supplement 1
Phase-amplitude coupling using a broader amplitude frequency range reveals that effects are specific to high gamma.
Comodulograms show PAC for (A) vertex and (B) precuneus stimulation sessions, and (C) comparison between precuneus and vertex stimulation sessions. Comodulograms displayed at p<0.05, cluster corrected.
Tables
Table 1
Theta power and phase coupling cluster information.
https://doi.org/10.7554/eLife.43114.007| Label | Size (voxels) | T | X | Y | Z |
|---|---|---|---|---|---|
| (A) Theta power: Elaboration > rest | |||||
| Bilateral occipital lobe, precuneus, cingulate cortex, inferior parietal and superior parietal lobes, retrosplenial cortex, MTL, mPFC, cerebellum | 4141 | 7.38 | −27 | −70 | 29 |
| (B) Theta phase coupling: Elaboration > rest | |||||
| Right occipital lobe | 38 | 5.54 | 28 | −70 | 16 |
| (C) Theta phase coupling: Precuneus > vertex | |||||
| Left occipital lobe | 24 | −5.30 | -2 | −90 | 6 |
Additional files
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Transparent reporting form
- https://doi.org/10.7554/eLife.43114.013
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A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval
eLife 8:e43114.
https://doi.org/10.7554/eLife.43114
