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A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval

  1. Melissa Hebscher  Is a corresponding author
  2. Jed A Meltzer
  3. Asaf Gilboa  Is a corresponding author
  1. Rotman Research Institute, Baycrest, Canada
  2. University of Toronto, Canada
  3. Northwestern University Feinberg School of Medicine, United States
Research Article
Cite this article as: eLife 2019;8:e43114 doi: 10.7554/eLife.43114
4 figures, 1 table, 1 data set and 1 additional file

Figures

Autobiographical memory paradigm.

Participants were cued with familiar words (locations, people, objects), and told to recall a past event in relation to this word. Construction was terminated when participants indicated they had an event in mind via button press.

https://doi.org/10.7554/eLife.43114.003
Figure 2 with 1 supplement
Exploratory between-subjects analysis showing that precuneus stimulation leads to (A) reduced vividness ratings and (B) reduced ease of recall compared to vertex stimulation when considering only the first session for each participant.

Asterisks indicate a significant difference between precuneus and vertex stimulation (p<0.05).

https://doi.org/10.7554/eLife.43114.004
Figure 2—source data 1

Behavioural data.

File contains data for Figure 2. Behavioral data for precuneus and vertex stimulation sessions are included, and the counterbalancing order (first session) is indicated.

https://doi.org/10.7554/eLife.43114.006
Figure 2—figure supplement 1
Exploratory between-subjects analysis showing non-significant differences between precuneus and vertex stimulation for (A) vividness and (B) ease of recall, when considering only the second session for each participant.
https://doi.org/10.7554/eLife.43114.005
Theta activity during autobiographical memory retrieval for vertex stimulation sessions.

(A) Theta power increases during AM retrieval relative to rest. (B) Increased theta phase coupling during AM retrieval using a right MTL seed (blue box). Theta power and phase coupling images displayed at p<0.005, cluster corrected. (C) Comodulogram showing theta-gamma phase-amplitude coupling between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines on comodulogram shows areas of significantly different phase-amplitude coupling between memory and rest. Comodulogram displayed at p<0.05, cluster corrected.

https://doi.org/10.7554/eLife.43114.008
Figure 3—source data 1

Data used for plotting comodulograms.

File contains data for panel C of Figure 3 (MTL-precuneus PAC), and data for non-significant mPFC and TPJ seeds.

https://doi.org/10.7554/eLife.43114.009
Figure 4 with 1 supplement
Effects of cTBS on theta activity during memory elaboration relative to rest.

(A) Precuneus stimulation led to decreased theta phase coupling between a right MTL seed (blue box) and the left occipital lobe. Images displayed at p<0.005, cluster corrected. (B) Comodulograms showing theta-gamma phase-amplitude coupling separately for vertex (left) and precuneus (right) stimulation sessions, between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines show areas of significantly different phase-amplitude coupling between memory and rest. (C) Comparison between comodulograms in (B), showing precuneus compared to vertex stimulation during memory retrieval, between right MTL theta phase and left precuneus gamma amplitude. Black dotted lines show areas of significantly different phase-amplitude coupling between precuneus and vertex stimulation. Comodulograms displayed at p<0.05, cluster corrected.

https://doi.org/10.7554/eLife.43114.010
Figure 4—source data 1

Data used for plotting comodulograms.

File contains data for panel C of Figure 4 (MTL-precuneus PAC), and data for non-significant mPFC and TPJ seeds.

https://doi.org/10.7554/eLife.43114.012
Figure 4—figure supplement 1
Phase-amplitude coupling using a broader amplitude frequency range reveals that effects are specific to high gamma.

Comodulograms show PAC for (A) vertex and (B) precuneus stimulation sessions, and (C) comparison between precuneus and vertex stimulation sessions. Comodulograms displayed at p<0.05, cluster corrected.

https://doi.org/10.7554/eLife.43114.011

Tables

Table 1
Theta power and phase coupling cluster information.
https://doi.org/10.7554/eLife.43114.007
LabelSize (voxels)TXYZ
(A) Theta power: Elaboration > rest
Bilateral occipital lobe, precuneus, cingulate cortex, inferior parietal and superior parietal lobes, retrosplenial cortex, MTL, mPFC, cerebellum41417.38−27−7029
(B) Theta phase coupling: Elaboration > rest
Right occipital lobe385.5428−7016
(C) Theta phase coupling: Precuneus > vertex
Left occipital lobe24−5.30-2−906

Data availability

All data generated during this study are included in the manuscript and supporting files. Source data files have been provided for Figures 2, 3C, and 4C.

The following data sets were generated
  1. 1
    Dryad Digital Repository
    1. M Hebscher
    2. JA Meltzer
    3. A Gilboa
    (2018)
    Data from: A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval.
    https://doi.org/10.5061/dryad.gf4f363

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