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Context-dependent signaling of coincident auditory and visual events in primary visual cortex

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Cite this article as: eLife 2019;8:e44006 doi: 10.7554/eLife.44006

Abstract

Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.

Article and author information

Author details

  1. Deneux Thomas

    Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    Competing interests
    The authors declare that no competing interests exist.
  2. Evan R Harrell

    Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    Competing interests
    The authors declare that no competing interests exist.
  3. Alexandre Kempf

    Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    Competing interests
    The authors declare that no competing interests exist.
  4. Sebastian Ceballo

    Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    Competing interests
    The authors declare that no competing interests exist.
  5. Anton Filipchuk

    Paris Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    Competing interests
    The authors declare that no competing interests exist.
  6. Brice Bathellier

    Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France
    For correspondence
    brice.bathellier@cnrs.fr
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9211-1960

Funding

Agence Nationale de la Recherche (Retour Postdoc)

  • Deneux Thomas
  • Brice Bathellier

Human Frontier Science Program (CDA)

  • Evan R Harrell
  • Brice Bathellier

H2020 European Research Council (ERC CoG)

  • Alexandre Kempf
  • Sebastian Ceballo
  • Anton Filipchuk
  • Brice Bathellier

Seventh Framework Programme (Marie Curie CiG)

  • Brice Bathellier

Fondation pour l'Audition (Lab grant)

  • Evan R Harrell
  • Brice Bathellier

École Doctorale Frontières du Vivant - Programme Bettencourt (Phd fellowship)

  • Alexandre Kempf

Paris-Saclay University (NeuroSaclay Brainscopes)

  • Brice Bathellier

Ecole des Neurosciences de Paris (Phd fellowship)

  • Sebastian Ceballo

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All animal procedures were approved by the French Ethical Committee (authorization 00275.01).

Reviewing Editor

  1. Karel Svoboda, Janelia Research Campus, Howard Hughes Medical Institute, United States

Publication history

  1. Received: November 29, 2018
  2. Accepted: May 20, 2019
  3. Accepted Manuscript published: May 22, 2019 (version 1)
  4. Accepted Manuscript updated: May 23, 2019 (version 2)
  5. Version of Record published: May 31, 2019 (version 3)

Copyright

© 2019, Thomas et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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