1. Neuroscience
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Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

  1. Alberto Llera  Is a corresponding author
  2. Thomas Wolfers
  3. Peter Mulders
  4. Christian F Beckmann
  1. Radboud University Nijmegen, Netherlands
  2. Donders Institute for Brain, Cognition and Behavior, Netherlands
  3. Radboud University Medical Centre, Netherlands
  4. Radboud University Medical Center, Netherlands
  5. University of Oxford, United Kingdom
Research Article
Cite this article as: eLife 2019;8:e44443 doi: 10.7554/eLife.44443
5 figures and 14 additional files

Figures

Data processing pipeline and main results.

(A) Structural and diffusion-weighted MRI data are used to extract relevant features, that is, Voxel-Based Morphometry (VBM), Fractional Anisotropy (FA), Mean Diffusivity (MD), Anisotropy Mode (MO), Cortical Thickness (CT), Pial Area (PA) and Jacobian Determinants (JD). (B) These features are used as input to the Linked ICA algorithm. (C) Subject loadings of each independent component are fed together with the behavioral/demographic measures into a correlation analysis. The bottom left panel presents demographic and behavioral measures grouped by categories (y-axis), and a representative set of components reflecting significant correlation with at least one behavioral measure (x-axis). The color-scale encodes the Pearson correlation coefficient and only significant correlations are color-coded. In the bottom right panel, we present a summary of component number six significant correlations to behavioral and demographic variates where the behavioral measures are grouped and ordered according to a decreasing correlation value. These results resemble a mode of structural variation that links to and extends the ‘positive-negative’ behavioral spectrum previously attributed to functional connectivity variations (Smith et al., 2015).

https://doi.org/10.7554/eLife.44443.003
Component number six feature sources of variation.

From top to bottom we visualize the VBM (Voxel Based Morphometry), JD (Jacobian Determinants), FA (Fractional Anisotropy), MD (Mean Diffusivity), MO (Mode of Anisotropy), PA (Pial Area), and CT (Cortical Thickness) spatial maps. For improved visualization, each modality has been thresholded at a z-value of 2. This mode of structural variation, component 6, that strongly reflects a ‘positive-negative’ behavioral spectrum, links to a wide range of brain regions across structural modalities and might reflect the structural multi-modal foundation of a functional brain network linked to these variations that has been earlier identified.

https://doi.org/10.7554/eLife.44443.004
Summary of relevant modalities spatial maps associated with the components indexed in the most left column.

For component one we show spatial maps for VBM and PA, and for components number 2 and 89 just VBM. For numbers 7 and 24 we present VBM, FA and CT. For number 20 we show VBM and JD and finally for numbers 25, 29 and 55 we present VBM and FA.

https://doi.org/10.7554/eLife.44443.005
Appendix 1—figure 1
Relative contributions of each feature modality to the most relevant components.
https://doi.org/10.7554/eLife.44443.021
Appendix 1—figure 2
Top: Significant correlations between the reported (100 dimensional) factorization and a 90 dimensional (left panel) and 110 dimensional (right panel).

Bottom: sorted absolute correlations for each of the components of the reported factorization with the other model orders components. The black discontinuous line represents component number 6.

https://doi.org/10.7554/eLife.44443.022

Data availability

All data analysed during this study are anonymised and publicly available from ConnectomeDB (db.humanconnectome.org; Hodge et al., 2016). It can be freely downloaded after creation of an account at "https://db.humanconnectome.org/app/template/Login.vm". Certain parts of the dataset used in this study, such as the age of the subjects, are available subject to restricted data usage terms, requiring researchers to ensure that the anonymity of subjects is protected (Van Essen et al., 2013). Relevant data generated by the analyses we performed are included in the manuscript and supporting files. Further details can be found at https://github.com/allera/Llera_elife_2019_1 (copy archived at https://github.com/elifesciences-publications/Llera_elife_2019_1).

Additional files

Supplementary file 1

Summary of the behavioral/demographic measures present in the HCP sample.

https://doi.org/10.7554/eLife.44443.006
Supplementary file 2

Significant results.

First column presents the component number, second the behavioral or demographic measure it correlates with and third and fourth columns present the correlation value and the permutation p-value. Significance is defined at p<0.05 and we used FDR correction for multiple correction (q < 2.2×10−4).

https://doi.org/10.7554/eLife.44443.007
Supplementary file 3

Comparison between the positive-negative mode presented in the main text and the multi-modal analyses excluding the JD feature (right column).

https://doi.org/10.7554/eLife.44443.008
Supplementary file 4

Summary of the uni-modal analyses using the JD feature.

In the second row all relationships are significant after multiple comparison correction. For the uni-modal analysis (the third row), significant associations after multiple comparison correction are denoted with a double asterisk and nominal significant but not significant after multiple comparison correction are marked with a single asterisk.

https://doi.org/10.7554/eLife.44443.009
Supplementary file 5

Linked ICA spatial maps associated with the FA feature.

https://doi.org/10.7554/eLife.44443.010
Supplementary file 6

Linked ICA spatial maps associated with the MD feature.

https://doi.org/10.7554/eLife.44443.011
Supplementary file 7

Linked ICA spatial maps associated with the MO feature.

https://doi.org/10.7554/eLife.44443.012
Supplementary file 8

Linked ICA spatial maps associated with the VBM feature.

https://doi.org/10.7554/eLife.44443.013
Supplementary file 9

Linked ICA spatial maps associated with the JD feature.

https://doi.org/10.7554/eLife.44443.014
Supplementary file 10

Linked ICA spatial maps associated with the left hemisphere CT feature.

https://doi.org/10.7554/eLife.44443.015
Supplementary file 11

Linked ICA spatial maps associated with the right hemisphere CT feature.

https://doi.org/10.7554/eLife.44443.016
Supplementary file 12

Linked ICA spatial maps associated with the left hemisphere PA feature.

https://doi.org/10.7554/eLife.44443.017
Supplementary file 13

Linked ICA spatial maps associated with the right hemisphere PA feature.

https://doi.org/10.7554/eLife.44443.018
Transparent reporting form
https://doi.org/10.7554/eLife.44443.019

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