Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

  1. Janelle Lauer
  2. Sandra Segeletz
  3. Alice Cezanne
  4. Giambattista Guaitoli
  5. Francesco Raimondi
  6. Marc Gentzel
  7. Vikram Alva
  8. Michael Habeck
  9. Yannis Kalaidzidis
  10. Marius Ueffing
  11. Andrei N Lupas
  12. Christian Johannes Gloeckner
  13. Marino Zerial  Is a corresponding author
  1. Max Planck Institute of Molecular Cell Biology and Genetics, Germany
  2. German Center for Neurodegenerative Diseases, Germany
  3. Heidelberg University, Germany
  4. Technical University Dresden, Germany
  5. Max Planck Institute for Developmental Biology, Germany
  6. Max Planck Institute for Biophysical Chemistry, Germany
  7. University of Tübingen, Germany
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  1. Janelle Lauer
  2. Sandra Segeletz
  3. Alice Cezanne
  4. Giambattista Guaitoli
  5. Francesco Raimondi
  6. Marc Gentzel
  7. Vikram Alva
  8. Michael Habeck
  9. Yannis Kalaidzidis
  10. Marius Ueffing
  11. Andrei N Lupas
  12. Christian Johannes Gloeckner
  13. Marino Zerial
(2019)
Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
eLife 8:e46302.
https://doi.org/10.7554/eLife.46302