Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

  1. Luis Sánchez-Guardado
  2. Carlos Lois  Is a corresponding author
  1. California Institute of Technology, United States

Abstract

Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.

Data availability

All data generated or analyzed during this study are included in the manuscript and supporting files.

Article and author information

Author details

  1. Luis Sánchez-Guardado

    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Carlos Lois

    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States
    For correspondence
    clois@caltech.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7305-2317

Funding

NIH Office of the Director (RO1MH116508)

  • Luis sanchez-guardado

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Stephen Liberles, Harvard Medical School, United States

Ethics

Animal experimentation: In all experiments, mice were handled according to the mice protocol (#1709) approved by the Institutional Animal Care and Use Committee (IACUC) of the California Institute of California.

Version history

  1. Received: March 8, 2019
  2. Accepted: August 26, 2019
  3. Accepted Manuscript published: August 27, 2019 (version 1)
  4. Version of Record published: September 13, 2019 (version 2)

Copyright

© 2019, sanchez-guardado & Lois

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Luis Sánchez-Guardado
  2. Carlos Lois
(2019)
Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
eLife 8:e46675.
https://doi.org/10.7554/eLife.46675

Share this article

https://doi.org/10.7554/eLife.46675

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