Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

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Abstract

Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.

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All data generated or analyzed during this study are included in the manuscript and supporting files.

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Luis Sánchez-Guardado

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States

Competing interests
The authors declare that no competing interests exist.
Carlos Lois

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States

For correspondence
clois@caltech.edu

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-7305-2317

Funding

NIH Office of the Director (RO1MH116508)

Luis sanchez-guardado

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: In all experiments, mice were handled according to the mice protocol (#1709) approved by the Institutional Animal Care and Use Committee (IACUC) of the California Institute of California.

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This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.