Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward size. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction.
The data used in this paper is available in:https://github.com/MatiJlab
- Mati Joshua
- Mati Joshua
- Noga Larry
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Animal experimentation: All the procedures described in this paper were approved in advance by the Institutional Animal Care and Use Committees of the Hebrew University of Jerusalem (ethics approval number MD15145854) and were in strict compliance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.
- Jennifer L Raymond, Stanford University School of Medicine, United States
© 2019, Larry et al.
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