Each colored point represents the divergence of a summary distribution computed on a simulated pool of sequences to the distribution of the same summary on a set of sequences drawn from one of 11 repertoires (Figure 5—figure supplement 1). Each black '+' represents a similar divergence but with a random selection from the training data rather than a simulated pool of sequences. A lower divergence means more similarity with respect to the given summary. The following summary statistics, applied to the CDR3 amino acid sequence, use Jensen-Shannon divergence: acidity, aliphatic index, aromaticity, basicity, bulkiness, length (in amino acids), charge, GRAVY index, nearest neighbor Levenshtein distance, pairwise Levenshtein distance, and polarity. The following summary statistics use divergence: CDR3 amino acid 2mer frequency, CDR3 amino acid frequency, J gene frequency, and V gene frequency.