1. Neuroscience
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Functional brain alterations following mild-to-moderate sensorineural hearing loss in children

  1. Axelle Calcus  Is a corresponding author
  2. Outi Tuomainen
  3. Ana Campos
  4. Stuart Rosen
  5. Lorna F Halliday
  1. Ecole Normale Supérieure, France
  2. University College London, United Kingdom
Research Article
  • Cited 5
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Cite this article as: eLife 2019;8:e46965 doi: 10.7554/eLife.46965

Abstract

Auditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditory evoked responses and mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 1, younger children with MMHL (8-12 years; n = 23) showed age-appropriate mismatch negativities (MMNs) to sounds, but older children (12-16 years; n = 23) did not. Six years later, we re-tested a subset of the younger (now older) children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings demonstrate that even a mild-to-moderate hearing loss during early-to-mid childhood can lead to changes in the neural processing of sounds in late childhood/adolescence.

Data availability

Unidentifiable data, stimuli, and statistical analyses scripts are available on https://github.com/acalcus/MMHL.git

The following data sets were generated

Article and author information

Author details

  1. Axelle Calcus

    Département d'Etudes Cognitives, Ecole Normale Supérieure, Paris, France
    For correspondence
    axelle.calcus@ens.fr
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-1240-1122
  2. Outi Tuomainen

    Department of Speech, Hearing and Phonetic Sciences, University College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
  3. Ana Campos

    Department of Speech, Hearing and Phonetic Sciences, University College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
  4. Stuart Rosen

    Department of Speech, Hearing and Phonetic Sciences, University College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
  5. Lorna F Halliday

    Department of Speech, Hearing and Phonetic Sciences, University College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.

Funding

H2020 Marie Skłodowska-Curie Actions (FP7-607139)

  • Axelle Calcus

ESRC National Centre for Research Methods, University of Southampton (RES-061-25-0440)

  • Lorna F Halliday

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: Informed consent, and consent to publish was obtained from parents/guardians of the children included in this study. Ethical approval for this study was provided by the UCL Research Ethics Committee (Project ID number: 2109/004).

Reviewing Editor

  1. Jonathan Erik Peelle, Washington University in St. Louis, United States

Publication history

  1. Received: March 18, 2019
  2. Accepted: September 7, 2019
  3. Accepted Manuscript published: October 1, 2019 (version 1)
  4. Version of Record published: November 4, 2019 (version 2)

Copyright

© 2019, Calcus et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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