Auditory deprivation in the form of deafness during development leads to lasting changes in central auditory system function. However, less is known about the effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. Here, we used a longitudinal design to examine late auditory evoked responses and mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 1, younger children with MMHL (8-12 years; n = 23) showed age-appropriate mismatch negativities (MMNs) to sounds, but older children (12-16 years; n = 23) did not. Six years later, we re-tested a subset of the younger (now older) children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings demonstrate that even a mild-to-moderate hearing loss during early-to-mid childhood can lead to changes in the neural processing of sounds in late childhood/adolescence.
Unidentifiable data, stimuli, and statistical analyses scripts are available on https://github.com/acalcus/MMHL.git
Functional Brain Alterations Following Mild-to-Moderate Sensorineural Hearing Loss in ChildrenGitHub, acalcus/MMHL.git.
- Axelle Calcus
- Lorna F Halliday
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Human subjects: Informed consent, and consent to publish was obtained from parents/guardians of the children included in this study. Ethical approval for this study was provided by the UCL Research Ethics Committee (Project ID number: 2109/004).
- Jonathan Erik Peelle, Washington University in St. Louis, United States
© 2019, Calcus et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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