1. Neuroscience

Shared neural underpinnings of multisensory integration and trial-by-trial perceptual recalibration in humans

  1. Hame Park  Is a corresponding author
  2. Christoph Kayser  Is a corresponding author
  1. Bielefeld University, Germany
https://doi.org/10.7554/eLife.47001
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  1. Hame Park
  2. Christoph Kayser
(2019)
Shared neural underpinnings of multisensory integration and trial-by-trial perceptual recalibration in humans
eLife 8:e47001.
https://doi.org/10.7554/eLife.47001
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Abstract

Perception adapts to mismatching multisensory information, both when different cues appear simultaneously and when they appear sequentially. While both multisensory integration and adaptive trial-by-trial recalibration are central for behavior, it remains unknown whether they are mechanistically linked and arise from a common neural substrate. To relate the neural underpinnings of sensory integration and recalibration, we measured whole-brain magnetoencephalography while human participants performed an audio-visual ventriloquist task. Using single-trial multivariate analysis, we localized the perceptually-relevant encoding of multisensory information within and between trials. While we found neural signatures of multisensory integration within temporal and parietal regions, only medial superior parietal activity encoded past and current sensory information and mediated the perceptual recalibration within and between trials. These results highlight a common neural substrate of sensory integration and perceptual recalibration, and reveal a role of medial parietal regions in linking present and previous multisensory evidence to guide adaptive behavior.

Data availability

The behavioral data presented in Figure 1 and LDA performance data and source regression data used to calculate the t-values in Figures 2-5, as well as data for Figure 4-figure supplement 1 have been deposited on Dryad (https://dx.doi.org/10.5061/dryad.t0p9c93).

The following data sets were generated

Article and author information

Author details

  1. Hame Park

    Department for Cognitive Neuroscience, Faculty of Biology, Bielefeld University, Bielefeld, Germany
    For correspondence
    hame.park@uni-bielefeld.de
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-2191-2055

  2. Christoph Kayser

    Department for Cognitive Neuroscience, Faculty of Biology, Bielefeld University, Bielefeld, Germany
    For correspondence
    christoph.kayser@uni-bielefeld.de
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-7362-5704

Funding

H2020 European Research Council (ERC-2014-CoG No 646657)

  • Christoph Kayser

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Ross K Maddox, University of Rochester, United States

Ethics

Human subjects: All participants submitted written informed consent. The study was conducted in accordance with the Declaration of Helsinki and was approved by the local ethics committee. Ethics Application No: 300140078 (College of Science and Engineering, University of Glasgow).

Version history

  1. Received: March 19, 2019
  2. Accepted: June 26, 2019
  3. Accepted Manuscript published: June 27, 2019 (version 1)
  4. Version of Record published: July 26, 2019 (version 2)

Copyright

© 2019, Park & Kayser

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Hame Park
  2. Christoph Kayser
(2019)
Shared neural underpinnings of multisensory integration and trial-by-trial perceptual recalibration in humans
eLife 8:e47001.
https://doi.org/10.7554/eLife.47001

Share this article

https://doi.org/10.7554/eLife.47001

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