Distinct subdivisions of human medial parietal cortex support recollection of people and places

  1. Edward H Silson  Is a corresponding author
  2. Adam Steel
  3. Alexis Kidder
  4. Adrian W Gilmore
  5. Chris I Baker
  1. National Institutes of Health, United States

Abstract

Human medial parietal cortex (MPC) is implicated in multiple cognitive processes including memory recall, visual scene processing and navigation, and is a core component of the default mode network. Here, we demonstrate distinct subdivisions of MPC that are selectively recruited during memory recall of either specific people or places. First, distinct regions of MPC exhibited differential functional connectivity with medial and lateral regions of ventral temporal cortex (VTC). Second, these same medial regions showed selective, but negative, responses to the visual presentation of different stimulus categories, with clear preferences for scenes and faces. Finally, and most critically, these regions were differentially recruited during memory recall of either people or places with a strong familiarity advantage. Taken together, these data suggest that the organizing principle defining the medial-lateral axis of VTC is reflected in MPC, but in the context of memory recall.

Data availability

Source data files have been provided for Figures 4 and 7 and Supplementary Figures 2, 3, & 4.

Article and author information

Author details

  1. Edward H Silson

    Laboratory of Brain and Cognition, National Institutes of Health, Bethesda, United States
    For correspondence
    ed.silson@nih.gov
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6149-7423
  2. Adam Steel

    Laboratory of Brain and Cognition, National Institutes of Health, Bethesda, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8876-933X
  3. Alexis Kidder

    Laboratory of Brain and Cognition, National Institutes of Health, Bethesda, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Adrian W Gilmore

    Laboratory of Brain and Cognition, National Institutes of Health, Bethesda, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8910-5009
  5. Chris I Baker

    Laboratory of Brain and Cognition, National Institutes of Health, Bethesda, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-6861-8964

Funding

This work was supported by the Intramural Research Program (ZIAMH002909) of the National Institutes of Health - National Institute of Mental Health Clinical Study Protocol 93 M-0170, NCT00001360.

Ethics

Human subjects: All participants gave written informed consent according to procedures approved by the NIH Institutional Review Board (protocol 93-M-0170, clinical trials # NCT00001360).

Copyright

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Metrics

  • 3,658
    views
  • 447
    downloads
  • 110
    citations

Views, downloads and citations are aggregated across all versions of this paper published by eLife.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Edward H Silson
  2. Adam Steel
  3. Alexis Kidder
  4. Adrian W Gilmore
  5. Chris I Baker
(2019)
Distinct subdivisions of human medial parietal cortex support recollection of people and places
eLife 8:e47391.
https://doi.org/10.7554/eLife.47391

Share this article

https://doi.org/10.7554/eLife.47391