Disease Risk: Mapping the emerging burden of dengue
The first nationally-representative survey of dengue has revealed the growing burden of the disease in Bangladesh.
- London School of Hygiene & Tropical Medicine, United Kingdom
Dengue is a viral disease spread by mosquitoes and found in more than 120 countries around the world (Bhatt et al., 2013). Because the species that transmits the disease, Aedes aegypti, lives in dense man-made environments, recent urbanization throughout the tropical world has accelerated the spread of dengue (Bhatt et al., 2013). Aedes aegypti is also the primary vector for a number of other diseases, including Zika, chikungunya and Yellow Fever, so understanding how to control the global emergence of dengue could help to prevent the spread of these diseases.
However, getting accurate data on who is being infected is surprisingly difficult. Only a small proportion of people (11–32%) are likely to have symptoms after contracting dengue, with few being sick enough to require formal medical care (Bhatt et al., 2013; Undurraga et al., 2013). And even if they receive medical care, misdiagnosis and under-reporting are common. This means that maps based on clinical case counts are not always useful, and may just reflect differences in access to healthcare, diagnostics and ability to report cases.
The gold standard for measuring who has been infected with dengue is a seroprevalence survey, where serum (blood) samples are taken from a representative group of people and tested for antibodies against the dengue virus. Now, in eLife, Henrik Salje and colleagues (who are based at institutes in France, the United States and Bangladesh) report how they have used this approach, which is usually reserved for local studies, on a scale never seen before to provide new insights into the transmission of dengue at a national level in Bangladesh (Salje et al., 2019).
Salje et al. visited 70 randomly selected communities across Bangladesh, between 2014 and 2016. During these visits, randomly selected residents were asked to contribute a blood sample and to answer a range of questions about behaviours thought to increase or decrease the risk of dengue. Overall, they found that 24% of participants showed evidence of previous dengue infection: this was much lower than the figures in other affected regions, such as Indonesia (~70%), where dengue has been around much longer (Tam et al., 2018). They also found that males were more likely to be infected than females, and that regular travellers were almost twice as likely to be infected as people who did not travel regularly.
However, the biggest factor in determining the risk of infection was location: over 80% of individuals in big cities, such as Dhaka, had been infected with the virus at some stage in their life, whereas fewer than 5% of people in rural areas showed signs of any previous infection. Using the results of their survey, Salje et al. were able to construct models that could predict seroprevalence in areas where data had not been collected, and then use this information to produce an updated risk map for dengue across Bangladesh (Figure 1).
Figure 1
Mapping dengue risk in Bangladesh.
A cross-sectional seroprevalence map (right) of dengue risk in Bangladesh, based on data collected from 70 communities throughout the country (Salje et al., 2019), shows that the risk is highest in the cities of Chittagong (in the south east), Khulna (south west) and Dhaka (in the middle of the country). Previous maps, such as this map based on data from Bhatt et al. (2013) (left), have predicted more widespread risk throughout the country, but these maps were largely based on less detailed data and often relied on extrapolation from nearby countries. This new study by Sajle et al. may suggest that there are unique, as yet unknown, factors that constrain the current distribution of dengue in Bangladesh.
By comparing seroprevalence between different age groups, Salje et al. were able to estimate the rate at which infections accumulate. Using standard 'catalytic models' (and making some assumptions about how long dengue has been in Bangladesh) they estimated that about 2.4 million people, out of a population of ~160 million, are infected with dengue virus in Bangladesh each year. In contrast fewer than 6,000 dengue cases per year were reported over the same time period, mostly in Dhaka (Mutsuddy et al., 2019). The results from this survey have the potential to play an important role in expanding and adapting dengue surveillance practices in Bangladesh.
Salje et al. also suggest that the current distribution of mosquito species in Bangladesh may be the cause of the limited spread of dengue. The mosquito that carries dengue, Aedes aegypti, was found in higher abundance in urban areas, whilst Aedes albopictus, a mosquito species that carries and transmits the virus less effectively, was more common in rural areas.
Together, these results paint a picture of a country part way through the emergence of dengue. Transmission is already high in urban centres but – unlike many countries in South East Asia and Latin America – regular, continuous transmission has yet to spread to more rural areas. However, more work is needed to understand how human movement and lower transmission potential in rural areas interact in shaping the current distribution of dengue in Bangladesh (Wesolowski et al., 2015). Genetic analyses of circulating dengue viruses can be used to identify the origins of outbreaks (Salje et al., 2017), which could help with efforts to contain the spread of the virus.
By proving the feasibility and value of nationally-representative seroprevalence surveys for dengue, it is hoped that the results of Salje et al. will renew interest in mass disease surveillance for dengue. Such community-representative surveys have proven instrumental for targeting and evaluating interventions for successful malaria control (Bhatt et al., 2015). A range of new dengue vaccines are currently becoming available, but some of these will only be beneficial if targeted to the areas of highest transmission (Flasche et al., 2016). Therefore, having regularly updated maps that accurately show the national spread of dengue will be critical in the ongoing fight against further expansion of the disease.
References
-
Dengue situation in Bangladesh: An epidemiological shift in terms of morbidity and mortalityCanadian Journal of Infectious Diseases and Medical Microbiology 2019:1–12.https://doi.org/10.1155/2019/3516284
-
Geographic variation in dengue seroprevalence and force of infection in the urban paediatric population of IndonesiaPLOS Neglected Tropical Diseases 12:e0006932.https://doi.org/10.1371/journal.pntd.0006932
-
Use of expansion factors to estimate the burden of dengue in Southeast Asia: A systematic analysisPLOS Neglected Tropical Diseases 7:e2056.https://doi.org/10.1371/journal.pntd.0002056
Article and author information
Author details
Publication history
Copyright
© 2019, Brady
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 3,442
- views
-
- 321
- downloads
-
- 7
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Disease Risk: Mapping the emerging burden of dengue
eLife 8:e47458.
https://doi.org/10.7554/eLife.47458
Further reading
-
- Epidemiology and Global Health
Artificially sweetened beverages containing noncaloric monosaccharides were suggested as healthier alternatives to sugar-sweetened beverages. Nevertheless, the potential detrimental effects of these noncaloric monosaccharides on blood vessel function remain inadequately understood. We have established a zebrafish model that exhibits significant excessive angiogenesis induced by high glucose, resembling the hyperangiogenic characteristics observed in proliferative diabetic retinopathy (PDR). Utilizing this model, we observed that glucose and noncaloric monosaccharides could induce excessive formation of blood vessels, especially intersegmental vessels (ISVs). The excessively branched vessels were observed to be formed by ectopic activation of quiescent endothelial cells (ECs) into tip cells. Single-cell transcriptomic sequencing analysis of the ECs in the embryos exposed to high glucose revealed an augmented ratio of capillary ECs, proliferating ECs, and a series of upregulated proangiogenic genes. Further analysis and experiments validated that reduced foxo1a mediated the excessive angiogenesis induced by monosaccharides via upregulating the expression of marcksl1a. This study has provided new evidence showing the negative effects of noncaloric monosaccharides on the vascular system and the underlying mechanisms.
-
- Epidemiology and Global Health
- Microbiology and Infectious Disease
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the contribution of this process to variability in annual epidemics is not well understood. Here, we link influenza A(H3N2) virus evolution to regional epidemic dynamics in the United States during 1997—2019. We integrate phenotypic measures of HA antigenic drift and sequence-based measures of HA and NA fitness to infer antigenic and genetic distances between viruses circulating in successive seasons. We estimate the magnitude, severity, timing, transmission rate, age-specific patterns, and subtype dominance of each regional outbreak and find that genetic distance based on broad sets of epitope sites is the strongest evolutionary predictor of A(H3N2) virus epidemiology. Increased HA and NA epitope distance between seasons correlates with larger, more intense epidemics, higher transmission, greater A(H3N2) subtype dominance, and a greater proportion of cases in adults relative to children, consistent with increased population susceptibility. Based on random forest models, A(H1N1) incidence impacts A(H3N2) epidemics to a greater extent than viral evolution, suggesting that subtype interference is a major driver of influenza A virus infection ynamics, presumably via heterosubtypic cross-immunity.
