(A) Average intensity ratings on the contralesional left forearm (NRH = 39, NHC = 20), (B) Average intensity ratings on the ipsilesional right forearm (NRH = 20, NHC = 20), (C) Average pleasantness …
Results for healthy controls are the same as presented in Figure 1. C, in light gray (NHC = 20). Error bars represent the standard error of the mean. Average pleasantness ratings on the …
Patients rated how pleasant it would be to be touched by a typically pleasant material (i.e. velvet) and a typically unpleasant fabric (i.e. sandpaper). Error bars represent the standard error of …
(A) Lesions associated with decreased CT pleasantness sensitivity on the contralesional left forearm, in all patients (N = 35). (B) Lesions associated with decreased CT pleasantness sensitivity on …
(A) Lesions overlap map for patients with negative CT pleasantness sensitivity on the left contralesional forearm, among all patients (N = 10). Out of the 10 patients that showed a negative CT …
A. with the CT pleasantness sensitivity scores for the contralesional left forearm as predictor, in all patients (N = 35); B. with the CT pleasantness sensitivity scores for the contralesional left …
A. Lesions associated with decreased CT pleasantness sensitivity on the contralesional left forearm, in all patients (N = 35) | ||||||
---|---|---|---|---|---|---|
Region | NVoxels | X | Y | Z | T-value | |
AAL | Unclassified | 104 | 43 | 1 | 19 | 2.88 |
Rolandic_Oper | 63 | 48 | -9 | 15 | 2.59 | |
JHU | Unclassified | 120 | 43 | 1 | 19 | 2.88 |
Superior_corona_radiata | 45 | 24 | 8 | 30 | 2.59 | |
NatBrainLab | Unclassified | 69 | 43 | 1 | 19 | 2.88 |
Arcuate_Anterior_Segment | 72 | 48 | -9 | 15 | 2.59 | |
Corpus_Callosum | 11 | 22 | 7 | 28 | 2.56 | |
Internal_Capsule | 15 | 25 | 5 | 27 | 2.56 | |
B. Lesions associated with decreased CT pleasantness sensitivity on the contralesional left forearm, only in patients without sensory deficit (N = 25) | ||||||
Region | NVoxels | X | Y | Z | T-value | |
AAL | Unclassified | 446 | 33 | 16 | -4 | 3.08 |
Frontal_Inf_Oper | 8 | 49 | 9 | 6 | 2.55 | |
Frontal_Inf_Orb | 8 | 35 | 25 | -8 | 2.77 | |
Rolandic_Oper | 88 | 37 | -4 | 20 | 2.57 | |
Insula | 598 | 38 | −12 | 12 | 3.06 | |
Putamen | 118 | 33 | -4 | 8 | 3.27 | |
Heschl | 24 | 44 | −17 | 8 | 2.65 | |
JHU | Unclassified | 1254 | 33 | -4 | 8 | 3.27 |
Superior_corona_radiata | 8 | 26 | 8 | 24 | 2.57 | |
External_capsule | 22 | 33 | -5 | 7 | 3.06 | |
Superior_longitudinal_fasciculus | 6 | 32 | -6 | 24 | 2.57 | |
NatBrainLab | Unclassified | 1277 | 33 | -4 | 8 | 3.27 |
Arcuate_Anterior_Segment | 11 | 37 | -5 | 21 | 2.57 | |
Inferior_Occipito_Frontal_Fasciculus | 1 | 37 | 2 | -8 | 2.54 | |
Internal_Capsule | 1 | 26 | 8 | 24 | 2.57 | |
C. Lesions associated with decreased CT pleasantness sensitivity on the ipsilesional right forearm (N = 41) | ||||||
Region | NVoxels | X | Y | Z | T-value | |
AAL | Frontal_Inf_Oper | 59 | 42 | 9 | 9 | 2.76 |
Rolandic_Oper | 79 | 45 | 4 | 9 | 2.76 | |
Insula | 32 | 45 | 3 | 8 | 2.70 | |
JHU | Unclassified | 170 | 45 | 4 | 9 | 2.76 |
NatBrainLab | Unclassified | 170 | 45 | 4 | 9 | 2.76 |
Description: Nottingham = Light Touch subscale of the Revised Nottingham Sensory Assessment (rNSA; Lincoln et al., 1998; score overall for each arm with 0: no sensation; 1: slightly impaired; 2: no …
Stroke Patients –RH (N = 59; 31 females) | Healthy Controls - HC (N = 20, 11 females) | Mann-Whitney Test | NRH/NHC | |||
---|---|---|---|---|---|---|
Mean | SD | Mean | SD | |||
Age (years) | 65.86 | 13.87 | 63.05 | 12.12 | U(78)=514.00, Z = -.857, p=0.391 | N = 59/20 |
Education (years) | 11.40 | 2.87 | 14.75 | 2.82 | U(70)=211.50, Z = −3.906, p<0.001* | N = 52/20 |
Days from onset | 16.95 | 18.68 | - | - | ||
Orientation | 2.80 | 0.41 | - | - | ||
Nottingham on left arm (max 2) | 0.66 | 0.78 | - | - | ||
Nottingham on right arm (max 2) | 2 | 0 | - | - | ||
Proprioception (max 9) | 5.10 | 2.64 | - | - | ||
MRC Left upper limb | 0.30 | 0.75 | - | - | ||
Digit span forwards | 5.95 | 1.40 | 6.58 | 1.83 | U(66)=279.50, Z = 0.936, p=0.349 | N = 56/12 |
Digit span backwards | 3.50 | 1.55 | 4.75 | 1.28 | U(66)=177.00, Z = −2.621, p=0.009* | N = 56/12 |
MOCA | 19.85 | 5.18 | 28.19 | 1.92 | U(45)=5.50, Z = −4.271, p<0.001* | N = 39/8 |
MOCA memory subscale | 2.92 | 1.78 | 4.00 | 1.60 | U(45)=95.00, Z = −1.769, p=0.077 | N = 39/8 |
Premorbid IQ-WTAR | 34.00 | 9.35 | 49.11 | 1.69 | U(25)=3.00, Z = −4.037, p<0.001* | N = 18/9 |
HADS depression | 5.75 | 3.49 | 3.13 | 2.19 | U(50)=150.00, Z = −2.593, p=0.010* | N = 37/18 |
HADS anxiety | 8.02 | 4.33 | 6.06 | 3.01 | U(50)=208.00, Z = −1.409, p=0.159 | N = 37/18 |
FAB total score | 11.38 | 4.02 | - | - | ||
Comb/razor test bias (%bias) | −23.37 | 27.06 | - | - | ||
Bisiach one item test | 0.47 | 0.68 | - | - | ||
Line crossing (max 36) | 22.56 | 11.85 | - | - | ||
Star cancelation (max 54) | 29.93 | 18.23 | - | - | ||
Copy | 0.87 | 1.20 | - | - | ||
Representational drawing | 0.62 | 0.93 | - | - | ||
Line bisection | 2.87 | 3.05 | - | - |
Number of significant voxels (from the atlas of gray matter – AAL – and white matter – JHU – and NatBrainLab’s atlas) resulting from the VLSM analysis with the general pleasantness sensitivity scores (velvet-sandpaper average pleasantness ratings), N = 36.
As control for a general pleasantness deficit, patients rated how pleasant it would be to be touched by a typically pleasant material (i.e. velvet, Mpleasantness rating = 6.91, SD = 1.88) and a typically unpleasant fabric (i.e. sandpaper, Mpleasantness rating = 0.33, SD = 0.93). Similarly, as for CT pleasantness sensitivity, top-down tactile pleasantness sensitivity was computed as the difference between pleasant (velvet) and unpleasant pleasantness ratings (sandpaper), for each patient. We considered the same patients as for the CT pleasantness sensitivity VLSM analysis (N = 36 as we had missing data for 5 of them) and ran a VLSM analysis with this top-down tactile pleasantness sensitivity.