Damage to the right insula disrupts the perception of affective touch
Abstract
Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch in right hemisphere stroke patients (N = 59), revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings corroborate previous imaging studies regarding the role of the posterior insula in the perception of affective touch. However, our findings about the crucial role of the anterior insula for ipsilateral affective touch perception open new avenues of enquiry regarding the cortical organization of this tactile system.
Data availability
The data that support the findings of this study are available on the Open Science Framework (https://osf.io/fyrwc/?view_only=75773c749be84432994beca994481988).
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Affective Touch Lesion StudyOpen Science Framework, fyrwc.
Article and author information
Author details
Funding
European Research Council (ERC-2012-STG GA313755)
- Aikaterini Fotopoulou
MIUR Italy (PRIN 20159CZFJK)
- Valentina Moro
University of Verona (Bando di Ateneo per la Ricerca di Base 2015 project MOTOS)
- Valentina Moro
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Stephen Liberles, Harvard Medical School, United States
Ethics
Human subjects: All participants gave written, informed consent to take part in the study and to publish. The local National Health System Ethics Committees approved the study (REC:05/Q0706/218), which was carried out in accordance to the Declaration of Helsinki.
Version history
- Received: April 23, 2019
- Accepted: January 23, 2020
- Accepted Manuscript published: January 24, 2020 (version 1)
- Version of Record published: February 26, 2020 (version 2)
Copyright
© 2020, Kirsch et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Further reading
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Evidence suggests that subcortical structures play a role in high-level cognitive functions such as the allocation of spatial attention. While there is abundant evidence in humans for posterior alpha band oscillations being modulated by spatial attention, little is known about how subcortical regions contribute to these oscillatory modulations, particularly under varying conditions of cognitive challenge. In this study, we combined MEG and structural MRI data to investigate the role of subcortical structures in controlling the allocation of attentional resources by employing a cued spatial attention paradigm with varying levels of perceptual load. We asked whether hemispheric lateralization of volumetric measures of the thalamus and basal ganglia predicted the hemispheric modulation of alpha-band power. Lateral asymmetry of the globus pallidus, caudate nucleus, and thalamus predicted attention-related modulations of posterior alpha oscillations. When the perceptual load was applied to the target and the distractor was salient caudate nucleus asymmetry predicted alpha-band modulations. Globus pallidus was predictive of alpha-band modulations when either the target had a high load, or the distractor was salient, but not both. Finally, the asymmetry of the thalamus predicted alpha band modulation when neither component of the task was perceptually demanding. In addition to delivering new insight into the subcortical circuity controlling alpha oscillations with spatial attention, our finding might also have clinical applications. We provide a framework that could be followed for detecting how structural changes in subcortical regions that are associated with neurological disorders can be reflected in the modulation of oscillatory brain activity.