Dopamine neuron ensembles signal the content of sensory prediction errors

  1. Thomas A Stalnaker  Is a corresponding author
  2. James D Howard
  3. Yuji K Takahashi
  4. Samuel J Gershman
  5. Thorsten Kahnt
  6. Geoffrey Schoenbaum  Is a corresponding author
  1. National Institute on Drug Abuse, National Institutes of Health, United States
  2. Northwestern University, United States
  3. Harvard University, United States
  4. University of Maryland School of Medicine, United States
  5. Johns Hopkins School of Medicine, United States
6 figures, 1 table and 1 additional file

Figures

Task design and behavior during recording.

Schematic (a) illustrates the order of events in trials at each well and the number and type of reward delivered at each well in the five trial-blocks performed in all recording sessions. Dashed …

https://doi.org/10.7554/eLife.49315.002
Dopamine neurons do not distinguish the identity of sensory prediction errors.

Plots show firing rates of dopamine neurons in response to transitions in number of reward drops (omission or delivery; a–c) and flavor (grape or tropical punch; d–f). Changes in firing rate in …

https://doi.org/10.7554/eLife.49315.003
Dopamine ensembles distinguish the identity of sensory prediction errors.

Heat plots show decoding of flavor by dopamine neuron ensembles, using data from a sliding window during trials after all three drops changed flavor (a) or when only the second drop changed flavor (b

https://doi.org/10.7554/eLife.49315.005
Human midbrain distinguishes the identity of sensory prediction errors.

(a) The reversal learning task involved binary choices between two visual cues to receive either a high or low concentration of one of two food odor rewards (one sweet [SW] and one savory [SV]). The …

https://doi.org/10.7554/eLife.49315.006
Author response image 1
Author response image 2

Tables

Table 1
Numbers of putative dopamine neurons recorded in each subject (subjects without dopamine neurons are not listed).
https://doi.org/10.7554/eLife.49315.004
Rat ID# Dopamine Neurons
AA016
AA059
AA061
AA074
AA093
AA101
AA126

Additional files

Download links