(A) Immunoblot analysis of IL10Rα expression in SVF and adipocyte fractions of iWAT from chow-fed 10 week-old mice. (B) Oxygen consumption (VO2, ml/hr), energy expenditure (EE, kCal/hr), and carbon dioxide production (VCO2, ml/hr) of chow-fed 10-week-old IL10RαF/F and AdIL10Rα KO mice were analyzed in Columbus Oxymax metabolic chambers (12 hr light/dark cycles, 72 hr total duration, each light/dark bar represents 12 hr duration). N = 9,7. Statistical analysis was performed using ANCOVA. (C) External appearance of representative 9 week HFD-fed mice. (D) Body weight of mice fed chow diet for 10 weeks and then 60% high-fat diet (HFD) for 9 weeks. N = 13, 7. (E) Fat and lean mass of mice in D fed HFD for 6 weeks. (F) Internal and gross appearance of iWAT from representative IL10RαF/F and AdIL10RαKO mice. *, p<0.05.