MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment
- University of Western Ontario, Canada
- Rotman Research Institute, Baycrest Hospital, Canada
- University of Guelph, Canada
Abstract
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardized outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer's disease, expanding knowledge of affected cognitive domains from male and female mice of three mouse strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.
Data availability
Automated quality control (QC) algorithm and the codes are available for free download and modification in GitHub https://github.com/srmemar/Mousebytes-An-open-access-high-throughput-pipeline-and-database-for-rodent-touchscreen-based-dataThe touchscreen processed data were deposited into an open-access application (http://www.mousebytes.ca/).
Article and author information
Author details
Funding
Weston Brain Institute
- Robert Bartha
- Stephen S Strother
- Boyer D Winters
- Marco A M Prado
Canada Open Neuroscience Platform
- Sara Memar
- Timothy J Bussey
- Marco A M Prado
Mitacs
- Daniel Palmer
- Lisa M Saksida
- Timothy J Bussey
CIFAR
- Lisa M Saksida
Canadian Institutes of Health Research (MOP136930)
- Marco A M Prado
Alzheimer's Society
- Vania F Prado
- Marco A M Prado
Canada First Research Excellence Fund (BrainsCAN)
- Robert Bartha
- Lisa M Saksida
- Timothy J Bussey
- Vania F Prado
- Marco A M Prado
Brain Canada
- Vania F Prado
- Marco A M Prado
Canadian Institutes of Health Research (MOP126000)
- Vania F Prado
- Marco A M Prado
Canadian Institutes of Health Research (MOP89919)
- Vania F Prado
- Marco A M Prado
Natural Sciences and Engineering Research Council of Canada
- Lisa M Saksida
- Timothy J Bussey
- Vania F Prado
Canada Research Chairs
- Lisa M Saksida
- Marco A M Prado
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Andrew Holmes, NIH, United States
Ethics
Animal experimentation: Procedures were conducted in accordance with approved animal protocols at the University of Western Ontario (2016/104) and the University of Guelph (3481) following the Canadian Council of Animal Care and National Institutes of Health guidelines.
Version history
- Received: June 24, 2019
- Accepted: December 11, 2019
- Accepted Manuscript published: December 11, 2019 (version 1)
- Version of Record published: December 27, 2019 (version 2)
Copyright
© 2019, Beraldo et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment
eLife 8:e49630.
https://doi.org/10.7554/eLife.49630
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