Neural mechanisms of economic choices in mice
- Department of Neuroscience, Washington University, United States
Figures
Figure 1
Economic choices in mice.
(a) Task diagram. In the experiments, mice chose between two liquid rewards (juices, schematized by the two lick tubes) offered in variable amounts. For each offer, the juice identity (water or …
Figure 2
Behavior, population analysis.
The figure illustrates the entire behavioral data set (19 mice). Each panel illustrates one behavioral measure, each row represents one mouse, and each data point represents one session. Relative …
Figure 3
LO inactivation disrupts economic decisions, example sessions.
(a) Effect of LO inactivation measured in a VGAT-ChR2 mouse. (b–f) Effect measured in PV-Cre+AAV-DIO-ChR2 mice. Each panel illustrates one session. Red data points represent trials in which area LO …
Figure 4
Effects of LO inactivation, relative value.
(a, b) Results for two VGAT-ChR2 mice. Each panel illustrates the results for one animal. The x- and y-axes represent the log relative value, log(ρ), measured under normal conditions (stimOFF) and …
Figure 5
Effects of LO inactivation, sigmoid steepness.
(a, b) Results for two VGAT-ChR2 mice. The x- and y-axes represent the sigmoid steepness (η) measured under normal conditions (stimOFF) and under LO inactivation (stimON), respectively. Each data …
Figure 6 with 3 supplements
Choice biases, example session.
(a) Example session (M57), same format as in Figure 1. (b–d) Choice biases. For the session in panel (a), the three panels illustrate the side bias (b), the choice hysteresis (c) and the direction …
Figure 6—figure supplement 1
Effects of LO inactivation, side bias.
Same format as in Figure 4. (a–h) Results for two VGAT-ChR2 mice (a,b) and five PV-Cre + AAV-DIO-ChR2 mice (c–g). The x- and y-axes represent the side bias (ε) measured under normal conditions …
Figure 6—figure supplement 2
Effects of LO inactivation, choice hysteresis.
Same format as in Figure 4. (a–h) Results for two VGAT-ChR2 mice (a,b) and five PV-Cre + AAV-DIO-ChR2 mice (c–g). For most mice, the distribution under LO inactivation is elongated on the y-axis – …
Figure 6—figure supplement 3
Effects of LO inactivation, direction hysteresis.
Same format as in Figure 4. (a–h) Results for two VGAT-ChR2 mice (a,b) and five PV-Cre + AAV-DIO-ChR2 mice (c–g). For most mice, the distribution under LO inactivation is elongated on the y-axis – …
Figure 7
Relation between choice deficit and infection in four brain areas.
Panels from left to right illustrate the results obtained for area LO, the olfactory bulb (OB), primary motor cortex (M1) and the medial orbital area (MO). In each panel, the x-axis represents the …
Figure 8
Choice deficits were not caused by motor impairments.
(a) Licking activity in one representative session (from mouse M41). The plot illustrates the licking frequency (y-axis) over the course of the trial under normal conditions (stim OFF) and under …
Figure 9
Encoding of decision variables, example neurons.
(a) Response encoding the offer value left (from left hemisphere, post-offer time window). In the left panel, firing rates are plotted against the offer type, and black dots show the behavior. …
Figure 10
Encoding of decision variables, population analysis.
(a) Explained responses. This panel shows, for each variable and for each time window, the number of responses explained. For example, 32 responses in the post-offer time window were explained by …
Figure 11
Variable selection analysis.
(a) Stepwise selection. The leftmost panel is as in Figure 10b. At each iteration, we identified the bin with the highest number of responses and we selected the corresponding variable. If the …
Figure 12
Reconstructed locations of neuronal recordings for six mice.
Recording regions for all animals were transferred on the same hemisphere. Approximate AP coordinate of this section is bregma 2.68 mm, interaural 6.48 mm.
Tables
Table 1
Results of ANOVAs.
The table reports the results of two ANOVAs. Each column represents one factor, each row represents one time window, and numbers represent the number of cells significantly modulated by the …
| 3-way | 1-way | |||
|---|---|---|---|---|
| Offer type | Position of A | Chosen side | Trial type | |
| Pre-offer | 1 | 4 | 6 | 8 |
| Post-offer | 55 | 35 | 102 | 121 |
| Late delay | 87 | 40 | 123 | 158 |
| Pre-juice | 39 | 27 | 127 | 121 |
| Post-juice | 58 | 28 | 150 | 155 |
| At least 1 | 154 | 85 | 308 | 301 |
Table 2
Variables defined in the analysis of neuronal responses.
| Variable | Definition | |
|---|---|---|
| 1 | position of A | Binary; one if juices A/B are offered on ipsi/contra sides, 0 otherwise |
| 2 | offer value A | Value of juice A offered |
| 3 | offer value B | Value of juice B offered |
| 4 | offer value ipsi | Value offered on the ipsi-lateral side |
| 5 | offer value contra | Value offered on the contra-lateral side |
| 6 | chosen value | Value of the chosen juice |
| 7 | chosen value A | Chosen value if juice A chosen, 0 otherwise |
| 8 | chosen value B | Chosen value if juice B chosen, 0 otherwise |
| 9 | chosen value ipsi | Chosen value if ipsi side is chosen, 0 otherwise |
| 10 | chosen value contra | Chosen value if contra side is chosen, 0 otherwise |
| 11 | chosen juice | Binary; one if juice A is chosen, 0 if juice B is chosen |
| 12 | chosen side | Binary; one if ipsi side is chosen, 0 if contra side is chosen |
