Reversal of contractility as a signature of self-organization in cytoskeletal bundles
- Université Paris-Saclay, CNRS, LPTMS, France
- PMMH, CNRS, ESPCI Paris, PSL University, Sorbonne Université, Université de Paris, France
Figures
Figure 1
Active motor-filament bundle dynamics involves a competition between contraction and extension.
(a) Motors bind filaments and move towards their plus ends. (b) This motion results in local contraction or extension depending on the local arrangement of the filaments. (c) In a full bundle, a …
Figure 2
Principles of filament, motor and cross-link dynamics.
(a) Simultaneous polymerization at the plus end (incoming purple monomers) and depolymerization from the minus end (outgoing white monomers) induce a leftwards ‘treadmilling’ motion of the filament. …
Figure 3
Filament force density profiles as in Equation 3.
(a) The crosslink density is suppressed near the plus end, implying that the crosslink force is predominantly applied to the right-hand-side of the filament. (b) When motors are faster than …
Figure 4
Velocity selection in the bundle.
(a) Profiles of the functions and , both of which go monotonically from 0 to 1 as goes from 0 to +∞. (b) Graphical illustration of the velocity selection condition Equation 4 as the …
Figure 5
Bundle tension.
(a) Level curves for the dimensionless bundle tension as a function of the apparent velocity determined from Equation 4 and pictured in Figure 4d, and the ratio . The purple line …
Figure 6
Comparison of the self-organization and buckling mechanisms (relevant for actin).
(a) At length scales of the order of the distance between consecutive motors and crosslinks (i.e., much smaller than those considered in the main text), filament buckling can generate an additional …
Figure 7
Comparison of the self-organization and dwelling mechanisms (relevant for microtubules).
(a) Dimensionless tensions induced by the self-organization (blue) and the dwelling (purple) mechanisms for . (b) Parameter regimes where either regime dominates for different values of (all …
Appendix 1—figure 1
