Physics of Living Systems

Latest articles

1. 1. Developmental Biology
   2. Physics of Living Systems

   Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early C. elegans development

   Lokesh G Pimpale et al.
2. 1. Cell Biology
   2. Physics of Living Systems

   The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

   Akanksha Thawani et al.

   Four αβ-tubulin dimers associate laterally on γ-TuRC to define the rate-limiting transition state for microtubule nucleation.
3. 1. Neuroscience
   2. Physics of Living Systems

   Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

   Joanne C Gordon et al.

   Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
4. 1. Ecology
   2. Physics of Living Systems

   Ant collective cognition allows for efficient navigation through disordered environments

   Aviram Gelblum et al.

   When real ants confront the classical 'Ant-in-a-labyrinth' physics problem where a random walker traverses a percolated environment, they employ active extended sensing and collective cognition to outperform passive physical solutions.
5. 1. Cell Biology
   2. Physics of Living Systems

   Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

   Anjali Jaiman, Mukund Thattai
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

   Rupamanjari Majumder et al.

   Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Nuclei determine the spatial origin of mitotic waves

   Felix E Nolet et al.

   Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
8. 1. Physics of Living Systems

   Mitigating memory effects during undulatory locomotion on hysteretic materials

   Perrin E Schiebel et al.

   Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
9. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   Chromosome organization by one-sided and two-sided loop extrusion

   Edward J Banigan et al.

   Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
10. 1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

    Marco Molari et al.