Physics of Living Systems

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   DNA sequence encodes the position of DNA supercoils

   Sung Hyun Kim et al.
2. 1. Developmental Biology
   2. Physics of Living Systems

   Theoretical tool bridging cell polarities with development of robust morphologies

   Silas Boye Nissen et al.

   Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.
3. 1. Neuroscience
   2. Physics of Living Systems

   Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

   Simon Bulley et al.

   Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
4. 1. Cell Biology
   2. Physics of Living Systems

   Morphogenetic degeneracies in the actomyosin cortex

   Sundar Ram Naganathan et al.

   Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.
5. 1. Cell Biology
   2. Physics of Living Systems

   Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

   Nicholas Mikolajewicz et al.

   Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   The Ca²⁺ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

   Colin M Rees et al.

   Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

   Rupamanjari Majumder et al.

   Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.
8. 1. Physics of Living Systems

   Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

   Feng-Ching Tsai et al.

   Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
9. 1. Physics of Living Systems

   Biophysical properties of single rotavirus particles account for the functions of protein shells in a multilayered virus

   Manuel Jiménez-Zaragoza et al.

   In triple-layered rotavirus particles, strong interaction between the external and middle layers provides high mechanical strength for protection tasks, while weaker interaction between the middle and inner layers favors transcription.
10. 1. Physics of Living Systems

    Dynamic density shaping of photokinetic E. coli

    Giacomo Frangipane et al.

    The concentration of motile bacteria, expressing a light-driven proton pump, can be precisely controlled in space and time by spatially modulating their swimming speeds with a structured light pattern.