Physics of Living Systems

Latest articles

1. 1. Physics of Living Systems

   Alternation emerges as a multi-modal strategy for turbulent odor navigation

   Nicola Rigolli, Gautam Reddy ... Massimo Vergassola

   A tracking animal's decision to intermittently pause and sniff the air reflects its belief that it is far downwind of the odor source, where benefits of sensing rare airborne cues outweigh the cost of pausing.
2. 1. Physics of Living Systems

   Navigation: Where is that smell coming from?

   Samuel Brudner, Thierry Emonet

   Computational model reveals why pausing to sniff the air helps animals track a scent when they are far away from the source.
3. 1. Immunology and Inflammation
   2. Physics of Living Systems

   Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

   Derek M Britain, Jason P Town, Orion David Weiner
4. 1. Evolutionary Biology
   2. Physics of Living Systems

   Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

   Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad

   Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
5. 1. Biochemistry and Chemical Biology
   2. Physics of Living Systems

   Recovering mixtures of fast-diffusing states from short single-particle trajectories

   Alec Heckert, Liza Dahal ... Xavier Darzacq

   Tracking proteins in live cells is challenging due to technical limitations and biological complexity, but approaches based in Bayesian nonparametrics stand a decent chance at recovering a target protein's dynamic profile from noisy data.
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

   Mark A Zaydman, Alexander S Little ... Arjun S Raman

   The emergent organization of bacterial proteomes—the integration of proteins into collective networks that encode function—can be defined purely from spectral analysis of ortholog covariation across extant diversity.
7. 1. Physics of Living Systems

   Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

   Joël Lemière, Paula Real-Calderon ... Fred Chang

   The volume of the nucleus is dictated by a balance of colloid osmotic forces from the nucleoplasm and cytoplasm.
8. 1. Cell Biology
   2. Physics of Living Systems

   Self-organization of kinetochore-fibers in human mitotic spindles

   William Conway, Robert Kiewisz ... Daniel J Needleman

   A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
9. 1. Physics of Living Systems

   3D single cell migration driven by temporal correlation between oscillating force dipoles

   Amélie Luise Godeau, Marco Leoni ... Daniel Riveline

   A phase shift between local contractions drives 3D cell motility in experiments and in model or how a finite area in the dipole-quadrupole space explains cell motion with zero total force.
10. 1. Physics of Living Systems

    Speed variations of bacterial replisomes

    Deepak Bhat, Samuel Hauf ... Simone Pigolotti

    The speed of replisomes in Escherichia coli depends on temperature and varies along the genome in a wave-like manner, with implications for bacterial physiology.