Physics of Living Systems

Latest articles

1. 1. Evolutionary Biology
   2. Physics of Living Systems

   Global epistasis emerges from a generic model of a complex trait

   Gautam Reddy, Michael M Desai

   Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
2. 1. Cell Biology
   2. Physics of Living Systems

   Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

   Manuel Giménez-Andrés et al.
3. 1. Physics of Living Systems

   Ligand sensing enhances bacterial flagellar motor output via stator recruitment

   Farha Naaz et al.
4. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

   Lakshya Chauhan et al.

   Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.
5. 1. Developmental Biology
   2. Physics of Living Systems

   Self-organized patterning of cell morphology via mechanosensitive feedback

   Natalie A Dye et al.
6. 1. Developmental Biology
   2. Physics of Living Systems

   From local resynchronization to global pattern recovery in the zebrafish segmentation clock

   Koichiro Uriu et al.

   Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
7. 1. Physics of Living Systems

   Robust, coherent and synchronized circadian clock-controlled oscillations along Anabaena filaments

   Rinat Arbel-Goren et al.
8. 1. Neuroscience
   2. Physics of Living Systems

   Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

   Aditya Raghunandan et al.

   A new tracer infusion method is used to confirm that pulsatile cerebrospinal fluid transport into the brain occurs naturally and is driven by the cardiac cycle, not by tracer injection.
9. 1. Physics of Living Systems

   Swarming bacteria undergo localized dynamic phase transition to form stress-induced biofilms

   Iago Grobas et al.

   Collective stress response via localized dynamic phase transition turns swarming Bacillus subtilis into biofilms.
10. 1. Physics of Living Systems

    Decoding the physical principles of two-component biomolecular phase separation

    Yaojun Zhang et al.

    Phase separation of two-component multivalent systems is suppressed at rational polymer stoichiometries, suggesting possible cellular strategies for regulating the formation and function of biomolecular condensates.