Physics of Living Systems

Latest articles

1. 1. Computational and Systems Biology
   2. Physics of Living Systems

   The Ca²⁺ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

   Colin M Rees et al.
2. 1. Physics of Living Systems

   Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

   Feng-Ching Tsai et al.
3. 1. Physics of Living Systems

   Biophysical properties of single rotavirus particles account for the functions of protein shells in a multilayered virus

   Manuel Jiménez-Zaragoza et al.

   In triple-layered rotavirus particles, strong interaction between the external and middle layers provides high mechanical strength for protection tasks, while weaker interaction between the middle and inner layers favors transcription.
4. 1. Physics of Living Systems

   Dynamic density shaping of photokinetic E. coli

   Giacomo Frangipane et al.

   The concentration of motile bacteria, expressing a light-driven proton pump, can be precisely controlled in space and time by spatially modulating their swimming speeds with a structured light pattern.
5. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Biophysical clocks face a trade-off between internal and external noise resistance

   Weerapat Pittayakanchit et al.

   Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
6. 1. Physics of Living Systems

   Point of View: Are theoretical results ‘Results’?

   Raymond E Goldstein

   There should be a prominent place for theory within biology papers, both as Results in papers that combine experiment and theory, and as Results in theory papers.
7. 1. Neuroscience
   2. Physics of Living Systems

   Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation

   Mochi Liu et al.

   Caenorhabditis elegans behavioral response to a mechanosensory signal depends on both the temporal properties of the signal, such as its rate of change, and the animal's current behavior state.
8. 1. Physics of Living Systems
   2. Computational and Systems Biology

   Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors

   Sebastian J Streichan et al.

   Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.
9. 1. Immunology and Inflammation
   2. Physics of Living Systems

   Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

   Victor Ovchinnikov et al.

   Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
10. 1. Developmental Biology
    2. Physics of Living Systems

    Gene-free methodology for cell fate dynamics during development

    Francis Corson, Eric D Siggia

    Mathematical methods based on geometry that directly embody the developmental concepts of competency, commitment, and determination provide succinct descriptions of morphogenesis and allow quantitative predictions from fits to sparse genetic data in Caenorhabditis elegans.