Physics of Living Systems

Physics of Living Systems

eLife publishes research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Physics of Living Systems

    Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

    Matthew A Heinrich et al.
    Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
    1. Neuroscience
    2. Physics of Living Systems

    Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures

    Tiberiu Tesileanu et al.
    An optimization principle allows natural-image data to predict human sensitivity to synthetic, un-natural textures with multiple gray levels.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Social interactions drive efficient foraging and income equality in groups of fish

    Roy Harpaz, Elad Schneidman
    Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.
    1. Ecology
    2. Physics of Living Systems

    Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

    Amir Erez et al.
    Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
    1. Cancer Biology
    2. Physics of Living Systems

    Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

    Xin Cui et al.
    A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

    Sriram Varahan et al.
    Sufficient aspartate drives specialization within a microbial colony, when some cells use it to create a limited carbon-resource, while other cells consume this resource and use aspartate for nucleotide synthesis.
    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo et al.
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
    1. Physics of Living Systems

    A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute

    Jonathan Desponds et al.
    Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors