Physics of Living Systems

Latest articles

1. 1. Physics of Living Systems

   High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

   Asher Preska Steinberg et al.

   Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
2. 1. Developmental Biology
   2. Physics of Living Systems

   Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

   Amelia J Thompson et al.

   During embryonic development, tissue stiffness, which provides an important signal to motile cells, changes locally within tens of minutes in a well-controlled manner.
3. 1. Physics of Living Systems

   Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation

   Anamika Agrawal et al.

   A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.
4. 1. Physics of Living Systems

   Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

   Albert Thommen et al.

   A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.
5. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   DNA sequence encodes the position of DNA supercoils

   Sung Hyun Kim et al.

   Single-molecule experiments reveal that plectonemic supercoils occupy specific positions on DNA and a physical model relates this to the intrinsic curvature, providing an insight into how supercoiling organizes the genome.
6. 1. Physics of Living Systems

   Measuring cis-regulatory energetics in living cells using allelic manifolds

   Talitha L Forcier et al.

   A novel strategy is presented for quantitatively measuring protein-DNA and protein-protein interactions that regulate transcription in living cells.
7. 1. Physics of Living Systems

   Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

   Ambjorn Brynnel et al.

   Genetically altering the size of the molecular spring element in the giant protein titin established that titin determines the stiffness of skeletal muscle and the number of sarcomeres in series.
8. 1. Developmental Biology
   2. Physics of Living Systems

   Theoretical tool bridging cell polarities with development of robust morphologies

   Silas Boye Nissen et al.

   Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.
9. 1. Neuroscience
   2. Physics of Living Systems

   Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

   Simon Bulley et al.

   Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
10. 1. Cell Biology
    2. Physics of Living Systems

    Morphogenetic degeneracies in the actomyosin cortex

    Sundar Ram Naganathan et al.

    Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.