Physics of Living Systems

Latest articles

1. 1. Physics of Living Systems

   Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

   William T Ireland et al.
2. 1. Developmental Biology
   2. Physics of Living Systems

   Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

   Matthew A Heinrich et al.

   Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
3. 1. Neuroscience
   2. Physics of Living Systems

   Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures

   Tiberiu Tesileanu et al.

   An optimization principle allows natural-image data to predict human sensitivity to synthetic, un-natural textures with multiple gray levels.
4. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Social interactions drive efficient foraging and income equality in groups of fish

   Roy Harpaz, Elad Schneidman

   Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.
5. 1. Ecology
   2. Physics of Living Systems

   Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

   Amir Erez et al.

   Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
6. 1. Cancer Biology
   2. Physics of Living Systems

   Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

   Xin Cui et al.

   A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
7. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

   Sriram Varahan et al.

   Sufficient aspartate drives specialization within a microbial colony, when some cells use it to create a limited carbon-resource, while other cells consume this resource and use aspartate for nucleotide synthesis.
8. 1. Neuroscience
   2. Physics of Living Systems

   Revealing architectural order with quantitative label-free imaging and deep learning

   Syuan-Ming Guo et al.

   Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
9. 1. Physics of Living Systems

   A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute

   Jonathan Desponds et al.

   Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.
10. 1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.

    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.