Physics of Living Systems

Latest articles

1. 1. Physics of Living Systems

   Single molecule microscopy reveals key physical features of repair foci in living cells

   Judith Miné-Hattab et al.

   Upon DNA damage, Rad52 forms a membraneless sub-compartment where Rad52 molecules are highly dynamic and share properties with liquid-liquid phase-separated molecules, reflecting the existence of a liquid droplet around damaged DNA.
2. 1. Physics of Living Systems
   2. Stem Cells and Regenerative Medicine

   DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

   Simona Hankeova et al.

   Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
3. 1. Physics of Living Systems
   2. Stem Cells and Regenerative Medicine

   Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

   Arne D Hofemeier et al.

   Combining global and local force measurements of reconstituted muscle tissue using a new chamber system that is compatible with high-resolution microscopy shows mechanical homeostasis already within a week.
4. 1. Physics of Living Systems

   Theory for the optimal detection of time-varying signals in cellular sensing systems

   Giulia Malaguti, Pieter Rein ten Wolde
5. 1. Developmental Biology
   2. Physics of Living Systems

   From local resynchronization to global pattern recovery in the zebrafish segmentation clock

   Koichiro Uriu et al.
6. 1. Physics of Living Systems

   Charge-driven condensation of RNA and proteins suggests broad role of phase separation in cytoplasmic environments

   Bercem Dutagaci et al.

   Charge complementarity between RNA and proteins may be a universal principle for phase separation in biology without requiring disorder or specific multivalent interactions.
7. 1. Physics of Living Systems
   2. Immunology and Inflammation

   Early life imprints the hierarchy of T cell clone sizes

   Mario U Gaimann et al.

   The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
8. 1. Physics of Living Systems

   Epithelial colonies in vitro elongate through collective effects

   Jordi Comelles et al.

   Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
9. 1. Cell Biology
   2. Physics of Living Systems

   Non-genetic inheritance restraint of cell-to-cell variation

   Harsh Vashistha et al.
10. 1. Neuroscience
    2. Physics of Living Systems

    Random access parallel microscopy

    Mishal Ashraf et al.

    A new imaging modality is described that can simultaneously record from several dishes without using robotics, which enables researchers to perform high-throughput, continuous measurements on biological samples.