From behavior to circuit modeling of light-seeking navigation in zebrafish larvae
- Laboratoire Jean Perrin, France
- Laboratoire de Physique de l'Ecole Normale Supérieure, France
Abstract
Bridging brain-scale circuit dynamics and organism-scale behavior is a central challenge in neuroscience. It requires the concurrent development of minimal behavioral and neural circuit models that can quantitatively capture basic sensorimotor operations. Here we focus on light-seeking navigation in zebrafish larvae. Using a virtual reality assay, we first characterize how motor and visual stimulation sequences govern the selection of discrete swim-bout events that subserve the fish navigation in the presence of a distant light source. These mechanisms are combined into a comprehensive Markov-chain model of navigation that quantitatively predict the stationary distribution of the fish's body orientation under any given illumination profile. We then map this behavioral description onto a neuronal model of the ARTR, a small neural circuit involved in the orientation-selection of swim bouts. We demonstrate that this visually-biased decision-making circuit can similarly capture the statistics of both spontaneous and contrast-driven navigation.
Data availability
Data and analysis codes are available at Dryad Digital: Data DOI: doi:10.5061/dryad.v9s4mw6qx
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From behavior to circuit modeling of light-seeking navigation in Zebrafish larvaeDryad Digital Repository, doi:10.5061/dryad.v9s4mw6qx.
Article and author information
Author details
Funding
Human Frontier Science Program (RGP0060/2017)
- Georges Debrégeas
H2020 European Research Council (71598)
- Volker Bormuth
Agence Nationale de la Recherche (ANR-16-CE16-0017)
- Raphaël Candelier
- Georges Debrégeas
Fondation pour la Recherche Médicale (FDT201904008219)
- Sophia Karpenko
ATIP-Avenir program
- Volker Bormuth
Fondation pour la Recherche Médicale (SPF201809007064)
- Sebastien Wolf
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All experiments were approved by Le Comité d'Éthique pour l'Expérimentation Animale Charles Darwin C2EA-05 (02601.01).
Reviewing Editor
- Gordon J Berman, Emory University, United States
Version history
- Received: October 19, 2019
- Accepted: January 2, 2020
- Accepted Manuscript published: January 2, 2020 (version 1)
- Version of Record published: January 29, 2020 (version 2)
Copyright
© 2020, Karpenko et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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From behavior to circuit modeling of light-seeking navigation in zebrafish larvae
eLife 9:e52882.
https://doi.org/10.7554/eLife.52882
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