Network dynamics underlying OFF responses in the auditory cortex

Abstract
Data availability
Article and author information

Abstract

Across sensory systems, complex spatio-temporal patterns of neural activity arise following the onset (ON) and offset (OFF) of stimuli. While ON responses have been widely studied, the mechanisms generating OFF responses in cortical areas have so far not been fully elucidated. We examine here the hypothesis that OFF responses are single-cell signatures of recurrent interactions at the network level. To test this hypothesis, we performed population analyses of two-photon calcium recordings in the auditory cortex of awake mice listening to auditory stimuli, and compared linear single-cell and network models. While the single-cell model explained some prominent features of the data, it could not capture the structure across stimuli and trials. In contrast, the network model accounted for the low-dimensional organisation of population responses and their global structure across stimuli, where distinct stimuli activated mostly orthogonal dimensions in the neural state-space.

Data availability

Python code and data are available at https://github.com/gbondanelli/OffResponses

The following previously published data sets were used

(2016) Data from: Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities
Nature Comm 7, 12682 (2016).

https://www.nature.com/articles/ncomms12682

Article and author information

Author details

Giulio Bondanelli

Laboratoire de Neurosciences Cognitives et Computationelles, Ecole Normale Superieure Paris, Paris, France

Competing interests
No competing interests declared.
Thomas Deneux

Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France

Competing interests
No competing interests declared.

"This ORCID iD identifies the author of this article:" 0000-0002-9330-7655
Brice Bathellier

Paris-Saclay Institute of Neuroscience, CNRS, Gif sur Yvette, France

Competing interests
Brice Bathellier, Reviewing editor, eLife.

"This ORCID iD identifies the author of this article:" 0000-0001-9211-1960
Srdjan Ostojic

Laboratoire de Neurosciences Cognitives et Computationelles, Ecole Normale Superieure Paris, Paris, France

For correspondence
srdjan.ostojic@ens.fr

Competing interests
No competing interests declared.

"This ORCID iD identifies the author of this article:" 0000-0002-7473-1223

Funding

Agence Nationale de la Recherche (ANR-16-CE37-0016)

Giulio Bondanelli
Srdjan Ostojic

Agence Nationale de la Recherche (ANR-17-EURE-0017)

Giulio Bondanelli
Srdjan Ostojic

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.