(A) Calcium fiber photometry schematic. OGB-1 was bolus-injected and an optic fiber with a diameter of 200 µm was implanted at a cortical depth of about 300 μm. Blue light was used for excitation of OGB-1. Emitted fluorescence, comprising the changes in cytosolic calcium concentration of the local neural population was collected by the same fiber, and recorded by the fiber optometer. (B) Characteristic signal traces of photometry recordings during slow wave activity induced by high isoflurane (SW-I, magenta), and persistent activity induced either by medetomidine (P-M, green) or by lower concentrations of isoflurane (blue, P–I). (C) Average of the correlation matrices (n = 6) of the mean BOLD signal in 96 cortical regions under low isoflurane concentration. (D) Matrix similarity analysis of the low isoflurane (P-I n = 6) persistent activity experiments compared with the average matrix generated under high isoflurane related slow wave activity (SW-activity, magenta) and the medetomidine-induced persistent activity (P-M, green), **p<0.01, (n = 6, paired t-test). (E) Matrix similarity observed under the three conditions under a dynamic connectivity analysis. Lines represent the average of individual variability for slow wave activity (SW-I, n = 15, magenta), persistent activity induced with medetomidine (P-M, n = 15, green) and persistent activity induced with isoflurane (P-I, n = 6 blue), the semitransparent stripe correspond to the standard error of the mean for each condition. The matrices were generated for a 5-min period with steps of 1 min and were compared with the average matrix generated in the first 5 min for each individual animal, **p<0.01 (paired t-test n = 15 in SW-I and P-M conditions).