Brain states govern the spatio-temporal dynamics of resting state functional connectivity
- Leibniz Institute for Resilience Research, Germany
- Johannes Gutenberg University Mainz, Germany
Abstract
Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017). Here, using the same techniques, we investigate two distinct cortical activity states: persistent activity, in which compartmentalized network dynamics were observed; and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. During slow wave activity we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. This study provides further evidence that changes in functional connectivity are dependent on the brain’s current state, directly linked to the generation of slow waves.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files. All source data files are available on Dryad Digital repository (https://doi.org/10.5061/dryad.vmcvdncqk). All custom Matlab codes used in these analyses are available at https://github.com/Strohlab/connectivityelife (Aedo-Jury & Stroh, 2020).
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Brain states govern the spatio-temporal dynamics of resting-state functional connectivityDryad Digital Repository, doi:10.5061/dryad.vmcvdncqk.
Article and author information
Author details
Funding
Deutsche Forschungsgemeinschaft (SFB 1193)
- Albrecht Stroh
Deutsche Forschungsgemeinschaft (SPP 1665)
- Albrecht Stroh
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: Animal husbandry and experimental manipulation were carried out according to animal welfare guidelines of the Johannes Gutenberg-University Mainz and were approved by the Landesuntersuchungsamt Rheinland-Pfalz, Koblenz, Germany. (G14-1-040).
Copyright
© 2020, Aedo-Jury et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Brain states govern the spatio-temporal dynamics of resting state functional connectivity
eLife 9:e53186.
https://doi.org/10.7554/eLife.53186
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