Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively
- Universitat Pompeu Fabra, Spain
- Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Abstract
Previous research showed that spontaneous neuronal activity presents sloppiness: the collective behavior is strongly determined by a small number of parameter combinations, defined as 'stiff' dimensions, while it is insensitive to many others ('sloppy' dimensions). Here, we analyzed neural population activity from the auditory cortex of anesthetized rats while the brain spontaneously transited through different synchronized and desynchronized states and intermittently received sensory inputs. We showed that cortical state transitions were determined by changes in stiff parameters associated with the activity of a core of neurons with low responses to stimuli and high centrality within the observed network. In contrast, stimulus-evoked responses evolved along sloppy dimensions associated with the activity of neurons with low centrality and displaying large ongoing and stimulus-evoked fluctuations without affecting the integrity of the network. Our results shed light on the interplay among stability, flexibility, and responsiveness of neuronal collective dynamics during intrinsic and induced activity.
Data availability
We made the spiking data publicly available here:https://github.com/adrianponce/Spont_stim_spiking_A1
Article and author information
Author details
Adrian Ponce-Alvarez
Funding
European Commission (Flag-Era JTC PCI2018-092891)
- Adrian Ponce-Alvarez
- Gustavo Deco
Horizon 2020 Framework Programme (785907 HBP SGA2)
- Gustavo Deco
Spanish Ministry of Economy and Competitiveness (PSI2016-75688-P)
- Gustavo Deco
Catalan Research Group Support (2017 SGR 1545)
- Gustavo Deco
Spanish Ministry of Economy and Competitiveness together with the European Regional Development Fund Grants (SAF2010-15730)
- Jaime de la Rocha
Spanish Ministry of Economy and Competitiveness together with the European Regional Development Fund Grants (SAF2013-46717-R)
- Jaime de la Rocha
Spanish Ministry of Economy and Competitiveness (Juan de la Cierva Fellowship IJCI-2014-21937)
- Gabriela Mochol
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All experiments were carried out in accordance with protocols approved by the Animal Ethics Committee of the University of Barcelona (Comité d'Experimentació Animal, Universitat de Barcelona, Reference: 116/13).
Copyright
© 2020, Ponce-Alvarez et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 1,827
- views
-
- 295
- downloads
-
- 17
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Citations by DOI
-
- 17
- citations for umbrella DOI https://doi.org/10.7554/eLife.53268
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively
eLife 9:e53268.
https://doi.org/10.7554/eLife.53268
