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Altered functional connectivity during speech perception in congenital amusia

  1. Kyle Jasmin  Is a corresponding author
  2. Frederic Dick
  3. Lauren Stewart
  4. Adam Taylor Tierney
  1. Department of Psychological Sciences, Birkbeck University of London, United Kingdom
  2. UCL Institute of Cognitive Neuroscience, University College London, United Kingdom
  3. Department of Experimental Psychology, University College London, United Kingdom
  4. Department of Psychology, Goldsmiths University of London, United Kingdom
Research Article
Cite this article as: eLife 2020;9:e53539 doi: 10.7554/eLife.53539
5 figures, 1 table, 1 data set and 1 additional file

Figures

Schematic of experimental paradigm.

(A) Example spectrograms of the early closure (top) and late closure (bottom) stimuli for the Both-Informative condition. Fundamental frequency contours are indicated with blue lines. The relative duration of the critical words are indicated with orange and green boxes. To the right, syntactic trees for the two sentences are shown to highlight the grammatical structure indicated by the phrase boundaries. (B) The time course of a single trial. Participants read a text version of the sentence from the screen, which was either early or late closure. This was followed by auditory presentation of the late and early closure versions. After both recordings were played, participants chose whether the first or second recording they heard matched the visually presentence sentence better. A single whole-brain volume was acquired after the button press, timed to capture the peak of the hemodynamic response roughly around presentation of the second sentence.

In-scanner performance.

Prosodic categorization performance measured in the scanner (proportion correct); each point represents the performance of a single participant.

Seed locations and group differences in seed-to-whole brain functional connectivity.

Inflated surfaces show the locations of False Discovery Rate-corrected group differences (Control > Amusia) in whole-brain connectivity (yellow crosses, minimum Z > 4.61), which were used as seeds in subsequent analyses (minimum Z > 3.57; warm colors indicate greater connectivity in the control than amusia participants). All four seed vertices were located in inferior frontal cortices (left inferior frontal gyrus, left DLPFC, right inferior frontal gyrus p. triangularis, and right inferior frontal gyrus p. orbitalis) (A) Significant group differences (Control > Amusia) in functional connectivity with left hemisphere seeds. The largest decreases in connectivity in the amusia group were located in right superior temporal plane and gyrus, the posterior middle temporal gyrus onto the inferior bank of the superior temporal sulcus, and anterior insula. (B) Significant group differences (control vs amusia) in functional connectivity with right hemisphere seeds. Prominent decreases in connectivity with the right inferior frontal gyrus in individuals with amusia were observed in the superior temporal plane and regions of occipital, frontal, and parietal cortex.

Connectivity between L DLPFC and insular (left) and auditory (right) cortex is modulated by normalized cue weights measured outside the scanner.

Correlation coefficients are Spearman rho.

Connectivity between L DLPFC and right insula (left) and between L DLPFC and right auditory cortex (right) were reduced in the amusia group during speech perception (Control >Amusia, p=0.0001 for both ROI pairs), but not during passive tone perception.

Tables

Table 1
Significant main effects of Group involving functional connectivity between seed areas and subcortical Structures.

All effects are Control > Amusia.

SeedRegion of interestF(1,87)p
L IFGR Accumbens15.430.0002
L DLPFCL Putamen15.780.0001459
R Putamen17.780.00006047
L Caudate25.230.0000027
R Caudate11.510.001044
L Cerebellum24.470.00000364
R Cerebellum16.230.0001194
L Pallidum14.600.0002484
R Pallidum12.440.0006739
L Thalamus14.830.0002245
R Thalamus15.720.0001501
R IFG (orbit)L Thalamus14.830.0002245
R IFG (triang.)L Accumbens10.100.002054

Data availability

The data that support the findings of this study are openly available in the Birkbeck repository (https://researchdata.bbk.ac.uk/65/), as are the speech stimuli (Jasmin et al., 2020b; https://researchdata.bbk.ac.uk/37/). The speech task can be demoed at the following link: (Gorilla Open Materials; https://gorilla.sc/openmaterials/102786).

The following data sets were generated
  1. 1
    Birkbeck Research Data
    1. K Jasmin
    2. F Dick
    3. L Stewart
    4. A Tierney
    (2020)
    Altered functional connectivity during speech perception in congenital amusia.
    https://doi.org/10.18743/DATA.00065

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