Primate homologs of mouse cortico-striatal circuits
- Department of Psychology, Royal Holloway University of London, United Kingdom
- Neural Control of Movement Laboratory, Department of Health Sciences and Technology, Switzerland
- Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, United Kingdom
- Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom
- Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Netherlands
Figures
Figure 1 with 1 supplement
Images illustrating the creation of mouse striatal seeds, their connectivity, and connectivity fingerprint matching.
(A) Schematic illustrating how mouse striatal seeds were created using tracer connectivity data from the Allen Institute. A connectivity matrix was extracted describing the volume of terminal label …
Figure 1—figure supplement 1
Figure showing the overlap between tracer-based and rsfMRI parcellations of the mouse striatum.
(A) The 33 cluster segmentation of Chon et al. (2019) from two representative slices. (B) Clusters from Chon et al. (2019) showed highly similar connectivity patterns and clustered into four …
Figure 2 with 4 supplements
Brain images show unthresholded striatal t-maps of mouse-human similarity for CP.m, NAcc, and CP.l.
Red-yellow voxels indicate increasingly positive correlations of connectivity fingerprints across species, blue-cyan voxels indicate increasing negative correlations of connectivity fingerprints …
Figure 2—figure supplement 1
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in mouse-human connectivity fingerprints for CP.m.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 2—figure supplement 2
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in mouse-human connectivity fingerprints for NAcc.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 2—figure supplement 3
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in mouse-human connectivity fingerprints for CP.l.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 2—figure supplement 4
Brain images show unthresholded striatal t-maps of mouse-human similarity for CP.m, NAcc, and CP.l.
Black outlines indicate voxels that showed statistically significant similarity (TFCE p<0.05). The unassigned voxels are a binary mask indicating voxels that did not met the criteria for …
Figure 3
Unthresholded whole-brain connectivity maps showing regions interconnected with human homologs of CP.m, NAcc, CP.l, and unassigned voxels.
The bottom row shows cerebellar activations on a flattened representation of the cerebellum and dotted black lines show the lobular boundaries (Diedrichsen and Zotow, 2015). The far-right column …
Figure 4 with 3 supplements
Brain images show unthresholded striatal t-maps of mouse-macaque similarity for CP.m, NAcc, and CP.l.
Red-yellow voxels indicate increasingly positive correlations of connectivity fingerprints across species, blue-cyan voxels indicate increasing negative correlations of connectivity fingerprints …
Figure 4—figure supplement 1
Images show axial slices through the macaque striatum including the unthresholded t-maps highlighting the similarity in mouse-macaque connectivity fingerprints for CP.m.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the macaque striatum. Black outlines highlight the voxels that show …
Figure 4—figure supplement 2
Images show axial slices through the macaque striatum including the unthresholded t-maps highlighting the similarity in mouse-macaque connectivity fingerprints for NAcc.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the macaque striatum. Black outlines highlight the voxels that show …
Figure 4—figure supplement 3
Images show axial slices through the macaque striatum including the unthresholded t-maps highlighting the similarity in mouse-macaque connectivity fingerprints for CP.l.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the macaque striatum. Black outlines highlight the voxels that show …
Figure 5
Unthresholded whole-brain connectivity maps showing regions interconnected with CP.m, NAcc, CP.l, and unassigned voxels.
The bottom row shows cerebellar activations. The far-right column shows a thresholded conjunction analysis of voxels that possess significantly greater connectivity with unassigned voxels compared …
Figure 6 with 4 supplements
Brain images show unthresholded striatal t-maps of macaque-human similarity for caudate body, NAcc, and putamen.
Red-yellow voxels indicate increasingly positive correlations of connectivity fingerprints across species, blue-cyan voxels indicate increasing negative correlations of connectivity fingerprints …
Figure 6—figure supplement 1
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in macaque-human connectivity fingerprints for caudate body.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 6—figure supplement 2
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in macaque-human connectivity fingerprints for NAcc.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 6—figure supplement 3
Images show axial slices through the human striatum including the unthresholded t-maps highlighting the similarity in macaque-human connectivity fingerprints for putamen.
The red-yellow/blue-cyan colourmap shows the degree of positive/negative similarity between mouse seed regions and voxels in the human striatum. Black outlines highlight the voxels that show …
Figure 6—figure supplement 4
Brain images with unthresholded striatal t-maps showing macaque-human similarity for Caudate Nucleus, NAcc, and Putamen.
Black outlines indicate voxels that showed statistically significant similarity (TFCE p<0.05). The unassigned voxels are a binary mask indicating voxels that did not met the criteria for …
Figure 7
Unthresholded whole-brain connectivity maps showing regions interconnected with caudate body, NAcc, putamen, and unassigned voxels.
The bottom row shows cerebellar activations on a flattened representation of the cerebellum and dotted black lines show the lobular boundaries (Diedrichsen and Zotow, 2015). The far-right column …
Figure 8
Brain images showing the spatial overlap of the NAcc across species.
Voxels highlight regions of statistically significant similarity across species (TFCE p<0.05). The light green outline in each image shows the anatomical boundaries of the human and macaque NAcc.
Additional files
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Supplementary file 1
Supplementary tables.
- https://cdn.elifesciences.org/articles/53680/elife-53680-supp1-v1.docx
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Transparent reporting form
- https://cdn.elifesciences.org/articles/53680/elife-53680-transrepform-v1.docx
