The frequency gradient of human resting-state brain oscillations follows cortical hierarchies
Abstract
The human cortex is characterized by local morphological features such as cortical thickness, myelin content, and gene expression that change along the posterior-anterior axis. We investigated if some of these structural gradients are associated with a similar gradient in a prominent feature of brain activity - namely the frequency of oscillations. In resting-state MEG recordings from healthy participants (N=187) using mixed effect models, we found that the dominant peak frequency in a brain area decreases significantly along the posterior-anterior axis following the global hierarchy from early sensory to higher-order areas. This spatial gradient of peak frequency was significantly anticorrelated with that of cortical thickness, representing a proxy of the cortical hierarchical level. This result indicates that the dominant frequency changes systematically and globally along the spatial and hierarchical gradients and establishes a new structure-function relationship pertaining to brain oscillations as a core organization that may underlie hierarchical specialization in the brain
Data availability
We have used online dataset for this study.
Article and author information
Author details
Funding
University of Muenster
- Keyvan Mahjoory
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (864.14.011)
- Jan-Mathijs Schoffelen
IZKF (Gro3/001/19)
- Joachim Gross
Deutsche Forschungsgemeinschaft (GR 2024/5-1)
- Joachim Gross
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Laura Dugué, Université de Paris, France
Version history
- Received: November 18, 2019
- Accepted: August 20, 2020
- Accepted Manuscript published: August 21, 2020 (version 1)
- Version of Record published: September 7, 2020 (version 2)
Copyright
© 2020, Mahjoory et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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