Attention-related modulation of caudate neurons depends on superior colliculus activity
- Laboratory of Sensorimotor Research, National Eye Institute, United States
- INSERM, CNRS Institut de la Vision, France
Figures
Figure 1 with 3 supplements
Experimental approach and behavioral effects of inactivation.
(A) In each session, the activity of neurons in the head of the caudate nucleus (CDh; blue shaded regions) was recorded with a pair of linear 32-channel probes before inactivation. An injection …
Figure 1—figure supplement 1
Performance summary comparing before and during SC inactivation broken down by SC inactivation side and subject.
Hit (filled symbols) and false-alarm rates (empty symbols) before SC inactivation are plotted against rates from the same sessions during SC inactivation. Rates for cue-ipsilateral to SC …
Figure 1—figure supplement 2
Inactivation-deficit area maps for all recording plus inactivation sessions (n = 13).
Each panel shows area occupied by motion-patch stimuli (gray-filled circles) and the estimated area of visual space affected by unilateral muscimol injection into the superior colliculus (SC). …
Figure 1—figure supplement 3
Electrode contact locations.
(A) Coronal MRI sections depicting recording target locations in monkey P at ‘AC +5’ (5 mm anterior to the anterior commissure). Yellow dots indicate approximate recording contact locations …
Figure 2
Example CDh neurons before and during SC inactivation.
(A) Activity of an example 'continuously isolated' CDh neuron recorded before same-side SC inactivation. Traces representing average spike counts in non-overlapping 50 ms bins are plotted separately …
Figure 3 with 4 supplements
Effects of same-side SC inactivation on cue-side preferences in continuously isolated CDh neuron subpopulation.
(A) Distribution of individual CDh across-task-epochs ROC areas (cue-side preferences) before same-side SC inactivation; colored bars indicate neurons with significant cue-contra (green; ROC area CI …
Figure 3—figure supplement 1
Effects of SC inactivation on CDh neuron firing rates.
(A) Average ROC area (cue-side preference) before (light line segments on black bars) and during (dark line segments on light bars) same-side SC inactivation in each task-epoch. Each line segment is …
Figure 3—figure supplement 2
Effects of opposite-side SC inactivation on cue-side preferences in continuously isolated CDh neuron subpopulation.
(A) Distribution of individual CDh across-task-epochs ROC areas (cue-side preferences) before opposite-side SC inactivation; colored bars indicate neurons with significant cue-contra (green; ROC …
Figure 3—figure supplement 3
Effects of same-side SC inactivation on cue-side preferences in continuously isolated CDh neuron subpopulation (monkey P).
(A) Distribution of individual CDh across-task-epochs ROC areas (cue-side preferences) before same-side SC inactivation; colored bars indicate neurons with significant cue-contra (green; ROC area CI …
Figure 3—figure supplement 4
Effects of same-side SC inactivation on cue-side preferences in continuously isolated CDh neuron subpopulation (monkey R).
(A) Distribution of individual CDh across-task-epochs ROC areas (cue-side preferences) before same-side SC inactivation; colored bars indicate neurons with significant cue-contra (green; ROC area CI …
Figure 4 with 3 supplements
Effects of SC inactivation on cue-side preferences in independent CDh neuron subpopulations.
(A) Cue-side preferences in each task-epoch (columns) for each CDh neuron (rows) recorded before same-side SC inactivation. Green areas indicate significant cue-contra preference, gray areas …
Figure 4—figure supplement 1
Effects of SC inactivation on cue-side preferences in independent CDh neuron subpopulations (monkey P).
(A) Cue-side preferences in each task-epoch (columns) for each CDh neuron (rows) recorded before same-side SC inactivation. Green areas indicate significant cue-contra preference, gray areas …
Figure 4—figure supplement 2
Effects of SC inactivation on cue-side preferences in independent CDh neuron subpopulations (monkey R).
(A) Cue-side preferences in each task-epoch (columns) for each CDh neuron (rows) recorded before same-side SC inactivation. Green areas indicate significant cue-contra preference, gray areas …
Figure 4—figure supplement 3
CDh cue-side preference changes during SC inactivation were unrelated to small saccadic eye movements (microsaccades).
(A) For each task-epoch, we chose a subset of trials in which no microsaccades (2°>amplitude > 0.35°) occurred in a time window including a 250 ms pre-epoch (light gray) and the epoch itself (dark …
Figure 5 with 2 supplements
Inactivation effects on CDh pairwise neuronal correlations.
(A) Before same-side SC inactivation density histogram of pairwise spike-count correlations pooled across epochs and cue-side presentations (n = 4280 pairs). (B) Presentation as in (A) but for …
Figure 5—figure supplement 1
Inactivation effects on CDh pairwise neuronal correlations (monkey P).
(A) Before same-side SC inactivation density histogram of pairwise spike-count correlations pooled across epochs and cue-side presentations (n = 2774 pairs). (B) Presentation as in (A) but for …
Figure 5—figure supplement 2
Inactivation effects on CDh pairwise neuronal correlations (monkey R).
(A) Before same-side SC inactivation density histogram of pairwise spike-count correlations pooled across epochs and cue-side presentations (n = 1506 pairs). (B) Presentation as in (A) but for …
Figure 6 with 2 supplements
Classifier analyses.
(A) A boosted decision tree classifier took n-dimensional vectors (where n is the number of simultaneously recorded neurons before or during SC inactivation) of CDh neuronal activity from individual …
Figure 6—figure supplement 1
Classifier analyses (monkey P).
(A) A boosted decision tree classifier took n-dimensional vectors (where n is the number of simultaneously recorded neurons before or during SC inactivation) of CDh neuronal activity from individual …
Figure 6—figure supplement 2
Classifier analyses (monkey R).
(A) A boosted decision tree classifier took n-dimensional vectors (where n is the number of simultaneously recorded neurons before or during SC inactivation) of CDh neuronal activity from individual …
