Deciphering the neural signature of human cardiovascular regulation
- Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Germany
- Institute of Aerospace Medicine, German Aerospace Center (DLR), Germany
- Chair of Aerospace Medicine, University of Cologne, Germany
Figures
Figure 1 with 2 supplements
Identification of cardiovascular centres in the human hypothalamus.
(a) Whole-brain T1-weighted study template showing the anatomical localisation of the hypothalamus. (b) Anatomical mask of the hypothalamus. (c) Brain activity was recorded during alternating …
Figure 1—figure supplement 1
Spatial independent components.
Complete set of specific spatially independent components as used for connectivity-based analyses in this study. Not shown are six components that were identified as noise.
Figure 1—figure supplement 2
Functional segmentation of the human hypothalamus.
(a) Anatomical subdivisions of the human hypothalamus as based on post-mortem anatomical studies (Dudás, 2013). Left: Hypothalamic regions in ventro-caudal direction. Right: Hypothalamic zones in …
Figure 2 with 5 supplements
Neural signature of cardiovascular control.
(a–e) Left: Individual hypothalamic centres derived from functional connectivity presented as mixture model thresholded probability maps. Centre: Normalised spectral BOLD signal changes (n = 22, …
Figure 2—figure supplement 1
Cardiovascular rhythms in the hypothalamus.
Left: Cardiovascular centres in the hypothalamus defined by functional connectivity (Figure 2). (a) right anterior right LH/SON; (b–c) bilateral tuberal LH/SON; (d) tuberal PVN; (e) arcuate nucleus. …
Figure 2—figure supplement 2
Functional segmentation of the human hypothalamus without and with physiological noise regression.
Segmentation is based on a masked independent component analysis of functional MRI data. The components were coloured to highlight the anatomical subdivisions of the human hypothalamus (Figure …
Figure 2—figure supplement 3
Functional connectivity changes during LBNP after physiological noise regression.
(a–e) First column: Individual cardiovascular hypothalamic regions presented as mixture model thresholded probability maps as derived from the main analysis (Figure 2). Second column: matched …
Figure 2—figure supplement 4
Cortical connectivity of the cardiovascular hypothalamic regions.
(a–e) Left: Individual cardiovascular hypothalamic regions presented as mixture model thresholded probability maps. Right: functional connectivity maps of the respective region, calculated using …
Figure 2—figure supplement 5
Comparison of the hypothalamic cardiovascular regions identified in this study and by Li and Dampney, 1994.
(a–e) Individual hypothalamic centres derived from functional connectivity presented as mixture model thresholded probability maps. These five centres fulfilled both criteria for cardiovascular …
Figure 3 with 1 supplement
PVN/PH as a hub in cardiovascular regulation.
(a) Three of the five hypothalamic cardiovascular centres derived from functional connectivity (Figure 2), namely PVN/PH (top), anterior LH/SON (middle), and arcuate nucleus (bottom) were also …
Figure 3—figure supplement 1
RVLM/Amb cluster increases functional connectivity to NTS during LBNP.
(a) Hypothalamic component encompassing the paraventricular nucleus and the posterior hypothalamic area. (b) Detail of the connectivity changes of (a) during LBNP that includes the rostral …
Figure 4
Central cardiovascular network.
Summary of the network nodes and links in the hypothalamus (a) and lower medulla oblongata (up until the level of the vagal nerve root) (b) as defined by functional connectivity. The central …
Additional files
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Supplementary file 1
Hypothalamic regions essential for cardiovascular control.
- https://cdn.elifesciences.org/articles/55316/elife-55316-supp1-v1.docx
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Supplementary file 2
Medullary regions essential for cardiovascular control.
- https://cdn.elifesciences.org/articles/55316/elife-55316-supp2-v1.docx
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Supplementary file 3
Coordinates and anatomical identification of spatial independent components.
- https://cdn.elifesciences.org/articles/55316/elife-55316-supp3-v1.docx
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Supplementary file 4
Coordinates and anatomical identification of dual regression clusters of Figure 2.
- https://cdn.elifesciences.org/articles/55316/elife-55316-supp4-v1.docx
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Supplementary file 5
Detailed MRI scan protocols.
Note that the reference scans for unwarping (Reference SE (no SMS; AP and PA)) are the same sequence but with inverted phase encoding direction. Hence, they are summarised in one table here. However, both sequences need to be acquired for estimating the susceptibility induced field.
- https://cdn.elifesciences.org/articles/55316/elife-55316-supp5-v1.docx
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Transparent reporting form
- https://cdn.elifesciences.org/articles/55316/elife-55316-transrepform-v1.docx
