(A) Black Curve – The single largest cluster as a function of free monomer concentration (in μM) for irreversible functional interactions. The largest cluster size is shown as a fraction of the total number of monomers in the simulation box. Purple Curve – The mean density of the cluster, = , normalized by the bulk density of monomers in the simulation, = . Sclus and Ntot refer to the size of the cluster and the total number of monomers in the simulation box, respectively. and refer to the radius of gyration of the cluster, and the radius of gyration of proteins in their randomly located initial configuration at the start of the simulation, respectively. The quantity / shows the degree of enrichment of polymer chains within the cluster upon self-assembly. The smooth curves are plotted as a guide to the eye, using the cspline curve fitting. (B) Comparison of the mean sizes of the single largest cluster for reversible and irreversible specific interactions, for varying free monomer concentrations. (C) Cluster size distributions for varying free monomer concentrations for reversible and irreversible specific interactions. Darker shades of red in the distributions indicate verlapping regions of the distribution while the blue and light red shades indicate regions with no overlap in the presence and absence of breakable interactions. The linker stiffness for the self-assembling polymer chains in this plot is 2 kcal/mol while the strength of inter-linker interaction is 0.1 kcal/mol (per pair of interacting beads). The mean and distributions of the largest cluster sizes were computed using 500 different configurations from five independent simulation runs of 16 μs.