Two-step cluster analysis of model parameters (ω3, μ30, κ , ω2) across rat and human data sets (rat, post-Rx; in laboratory and online version 3, block 1). Automated clustering yielded an optimal two clusters with good cohesion and separation (average silhouette coefficient = 0.7; cluster size ratio = 2.46). (a) Density plots for μ30, κ, ω2, and ω3 (light pink) depict cluster-specific distributions for each parameter (red). Unlike frequency histograms (that depict the number of data points in bins), density plots employ smoothing to prioritize distribution shape and are not restricted by bin size. Beneath each density plot, box-plots of overall median, 25th quartile, and 75th quartile for each parameter are aligned (pink), with cluster medians and quartiles superimposed (red). Relative to the overall distribution, Cluster 1 (n = 35) medians are elevated for μ30 and κ, decreased for ω2 and ω3. Cluster 2 (n = 86) falls within each overall distribution. (b) Predictor importance of included parameters. Consistent with the color scheme in Figure 2a, Uncertainty weighting parameters (κ, ω2, ω3 ) are depicted in purple and μ30 the prior is in blue. (c) Distribution of cluster identities within groups. Black bars signify the proportion of group members assigned to Cluster one and gray bars represent the proportion of group members assigned to Cluster 2. Cluster one membership is significantly associated with paranoia and methamphetamine groups (χ2(1, n = 121)=29.447, p=5.75E-8). Columns display means [standard error] or percentage of participants within the described category, test-statistics, and p-values. †Independent samples t-test: t-value (df). Two-tailed P-values reported. ‡Chi square coefficient (df). §Fisher’s exact test, exact significance (2-sided). ¶Equal variances not assumed. #Not significant (Bonferonni correction). ††Data presented in Figure 8; repeated measures ANOVA, paranoia group trend or effect: F(df), P; estimated marginal means and standard error. ‡‡Data presented in Figure 2; repeated measures ANOVA, F(df), P. In laboratory: paranoia x block interactions for ω3, μ30; paranoia group effects for κ, ω2. Version 3: paranoia group effects reported. See Table 3 for complete ANOVA. results. Version columns display means [standard error] or percentage of participants within the described category. ††Univariate analysis, F(df). ‡Exact test, chi-square coefficient (df). § Exact significance (2-sided). ||Monte Carlo significance (2-sided). ‡‡Data presented in Figure 3; repeated measures ANOVA, F(df), P. Mean values collapsed across blocks.