Mesoscopic-scale functional networks in the primate amygdala
- University of Arizona, United States
- Radboud University Nijmegen, Netherlands
Abstract
The primate amygdala performs multiple functions that may be related to the anatomical heterogeneity of its nuclei. Individual neurons with stimulus- and task-specific responses are not clustered in any of the nuclei, suggesting that single-units may be too-fine grained to shed light on the mesoscale organization of the amygdala. We have extracted from local field potentials recorded simultaneously from multiple locations within the primate (Macaca mulatta) amygdala spatially defined and statistically separable responses to visual, tactile, and auditory stimuli. A generalized eigendecomposition-based method of source separation isolated coactivity patterns, or components, that in neurophysiological terms correspond to putative subnetworks. Some component spatial patterns mapped onto the anatomical organization of the amygdala, while other components reflected integration across nuclei. These components differentiated between visual, tactile, and auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.
Data availability
All source data (i.e., the raw LFP from all recording sessions) have been deposited in the Zenodo repository (https://doi.org/10.5281/zenodo.3752137). The MATLAB scripts and supporting Excel data files used to process the data shown in each figure are provided with this submission.
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Raw LFP data from Gothard Lab Multisensory processing ProjectZenodo, 10.5281/zenodo.3752137.
Article and author information
Author details
Funding
National Institute of Mental Health (P50MH100023)
- Katalin M Gothard
National Institute of Mental Health (R01MH121009)
- Katalin M Gothard
European Research Council (StG 638589)
- Michael X Cohen
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All procedures comply with the NIH guidelines for the use of non-human primates in research as outlined in the Guide for the Care and Use of Laboratory Animals and have been approved by the Institutional Animal Care and Use Committee of the University of Arizona (protocol #08‐101).
Copyright
© 2020, Morrow et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Mesoscopic-scale functional networks in the primate amygdala
eLife 9:e57341.
https://doi.org/10.7554/eLife.57341
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