(A) Afferents from the vestibular periphery project to three classes of neurons found in the vestibular nuclei. Position-vestibular-pause (PVP, magenta) and eye-head (EH, blue) neurons project to extraocular motoneurons within the abducens nucleus and mediate reflexive behaviors such as the vestibulo-ocular reflex (VOR). Vestibular-only (VO, green) neurons project to the ventral posterolateral (VPL) nucleus of the Thalamus, thereby mediating self-motion perception, as well as to the spinal cord, mediating vestibulo-spinal reflexes. Recordings were made from PVP, EH and VO neurons. (B) Top: Spike train power spectra of example PVP (left), EH (middle), and VO (right) neurons that display high variability. Bottom: Spike train power spectra of example PVP (left), EH (middle), and VO (right) neurons that display low variability. The orange bands indicated by the red arrows show the frequency range of naturalistic head motion stimuli (0–20 Hz). The insets show the interspike interval (ISI) distribution for each example neuron. (C) Firing rate as a function of the ISI coefficient of variation (CV). In all three cases, there was no significant correlation (PVP: R = −0.08, p=0.71; EH: R = −0.29, p=0.29; VO: R = −0.38, p=0.13). The dashed black curves show the distributions for all data. The six example neurons shown in panel B are represented by open symbols. (D) Top: Population-averaged firing rates for PVP, EH, and VO neurons did not differ significantly from one another (one-way ANOVA, F(2,51) = 2.31, p=0.11). Bottom: Population-averaged CV values for PVP, EH, and VO neurons. The CV of VO neurons was more broadly distributed than that of PVP and EH neurons (Levene’s test F = 7.2, p=0.001) while the distribution of the firing rate was similar for all classes of neuron (Levene’s test F = 0.87, p=0.43). PVP neurons displayed lower CV values than VO and EH neurons on average (one-way ANOVA, F(2,51) = 3.58, p=0.03).