Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex
- Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin–Madison, United States
- WiSys Technology Foundation, United States
Figures
Figure 1 with 1 supplement
Task, stimuli, and performance.
(A) Tilt discrimination task. After fixating a target at the center of the screen for 300 ms, a plane was shown for 1 s while fixation was maintained. The target and plane then disappeared and eight …
Figure 1—figure supplement 1
Behavioral performance.
(A) Proportion of choices made for each tilt option at each combination of tilt (colors), slant (rows), and distance (supercolumns) for each monkey (subcolumns). Performance was near perfect at …
Figure 2
Neuronal recordings.
Coronal MRI sections showing the estimated boundaries of CIP (light blue) and neighboring regions (see Materials and methods). All recording locations (green circles) are shown projected along the …
Figure 3 with 1 supplement
3D orientation tuning at each distance before the onset of choice-related activity.
(A-E) Five example neurons. Heat maps show firing rate as a function of tilt (T) and slant (S), plotted using the coordinates illustrated in Figure 1B. Red hues indicate higher firing rates. …
Figure 3—figure supplement 1
Response time course and Tolerance distributions.
(A) Spike density functions showing the responses of the example neuron in Figure 3B (green) and the population (pink, N = 437) to preferred (solid lines) and non-preferred (dashed lines) stimuli. …
Figure 4
Neuronal correlates of 3D tilt sensitivity.
(A) Mean behavioral tilt sensitivity () and neuronal tilt discrimination index (TDI) values during the SD window increased with slant. Data points show mean and SEM across distances and monkeys or …
Figure 5 with 2 supplements
Choice tuning was parametric and aligned with the tilt preferences.
(A) Time course of choice-related activity. Curves show z-scored responses averaged over neurons for each of the eight choices relative to each neuron’s preferred choice. Stimulus onset = 0 ms. …
Figure 5—figure supplement 1
Validation of the choice-related activity results.
(A-D) Choice tuning curves computed over full and short duration SPC windows were similar. (A) Choice tuning in the full and short SPC windows for the neuron in Figure 5D. (B) Difference between …
Figure 5—figure supplement 2
Experience-dependent association of choice reports and orientation selectivity.
The direction of choice reports had opposite effects on neuronal activity when monkeys were trained to report the plane’s near side (A,C) versus far side (B,D). Each panel shows the full 3D …
Figure 6
3D orientation tuning at each distance after the onset of choice-related activity.
(A-E) The example neurons (Figures 3A–E and 5B–F, same order). (A) Tolerance increased from 0.88 (SD window) to 0.96 (SPC window). (B) Tolerance increased from 0.53 to 0.88. Note the changes in …
Figure 7 with 1 supplement
Choice-related activity was associated with more robust 3D selectivity.
(A) Tolerance values in the SD window for neurons with (orange) and without (gray) choice-related activity. (B) Tolerance values in the SPC window for neurons with (blue) and without choice-related …
Figure 7—figure supplement 1
Parametric analysis of 3D orientation tuning curve shape.
Bingham functions describe the orientation tuning curves of CIP neurons (Rosenberg et al., 2013). Three parameters set the bandwidth (λ2 ≥ 0), isotropy (λ1 ≤ 0), and orient the major/minor axes (0° …
Figure 8
Saccade-related activity and sensorimotor associations.
(A) Saccade task. A target was fixated for 1.3 s after which it disappeared and a saccade target appeared at one of eight locations. A saccade was then made to that target. (B) Time course of …
Figure 9
Sensorimotor and choice-motor associations.
(A) Differences between principal surface tilts and saccade direction preferences for neurons with choice-related activity (N = 135). (B) Same as A, but for neurons without choice-related activity …
Figure 10
The robustness of 3D selectivity was associated with choice-related activity but not saccade-related activity.
(A-C) Neurons with choice-related activity. (A) Tolerance values in the SD window for neurons with (brown) and without (gray) saccade-related activity. (B) Tolerance values in the SPC window for …
