(A) Base-pair proximities of CpGs to Transcription Start Sites (TSS), according to module assignment (denoted by color). We find a high proportion of CpGs in the blue module (and to some extent the green module) are located 10,000 to 1,000,000 downstream of TSS. (B) Proportion of CpGs in various genomic regions as a function of module (denoted by color). Results suggest that 98% of CpGs in the blue module and 60% of CpGs in the green module are in intergenic regions. (C) Distribution of surrounding CpGs densities according to module (denoted by color). CpG density was (x-axis) was calculated as the number of CpGs within a 100 bp window (50 bp on either side of the CpG of interest). We observed that the blue module tended to be comprised of CpGs located in regions of higher CpG density (island), while the green module was bimodal, with half the CpGs in it being located in high-density regions, and the other half in low-density regions. (D) We then plotted CpG density as a function of the CpG loading for PC1 that was used to estimate DNAmAge from overlapped CpGs. We find that for the green module, CpGs with strong negative loadings are in low-density regions, while those with high loadings are in both low- and high-density regions.