Chimpanzee brain morphometry utilizing standardized MRI preprocessing and macroanatomical annotations
- Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine-University, Germany
- Institute of Neuroscience and Medicine (INM-7) Research Centre Jülich, Germany
- Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, United States
- Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, United States
- Department of Experimental Medicine, University of Copenhagen, Denmark
- Department of Psychology, Georgia State University, United States
- Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany
- Institute for Anatomy I, Medical Faculty, Heinrich-Heine-University, Germany
- JARA-BRAIN, Jülich-Aachen Research Alliance, Germany
- Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Germany
- Structural Brain Mapping Group, Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany
- Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Denmark
Figures
Figure 1
Juna.Chimp templates including the average.
T1- template, tissue probability maps (TPM), and Geodesic Shooting template. For Shooting templates and TPM axial slices are shown of gray matter (GM), white matter (WM), and cerebrospinal fluid …
Figure 2
Lateral and medial aspect of the Davi130 parcellation right hemisphere.
Visible regions are numbered with Davi130 parcellation region numbers and correspond to names in the figure. Even numbers correspond to regions in the right hemisphere (as shown in the figure), …
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Figure 2—source data 1
Source file for Complete List of Davi130 Labels.
- https://cdn.elifesciences.org/articles/60136/elife-60136-fig2-data1-v2.docx
Figure 3 with 2 supplements
Total gray matter volume decline during aging in chimpanzees and matched human sample.
(A) Distribution of age and sex in the final sample of 194 chimpanzees. (B) Linear relationship between GM and age with standard error for chimpanzee sample. (C) Distribution of age and sex in the …
Figure 3—figure supplement 1
Age and sex distribution of complete chimpanzee (n = 223) sample separated by scanner field strength.
Figure 3—figure supplement 2
Age and sex distribution of complete IXI human sample (n = 496) separated by scanner field strength.
Figure 4
Region-wise morphometry in the Davi130 parcellation age regression.
Red regions represent Davi130 regions that remained significant at p≤0.05 following FWE correction (Holm method). The T-statistic and p-value for all Davi130 labels can be found in Figure 4—source …
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Figure 4—source data 1
Aging effect on gray matter in complete Davi130 Labels.
- https://cdn.elifesciences.org/articles/60136/elife-60136-fig4-data1-v2.docx
Figure 5 with 1 supplement
Voxel-based morphometry of aging on GM volume.
The significant clusters are found using TFCE with FWE correction at p≤0.05.
Figure 5—figure supplement 1
Voxel-based morphometry of aging on GM volume using TFCE with FWE correction at p≤0.05 without rearing as a covariate.
Figure 6
Hemispheric asymmetry of Davi130 regions within the chimpanzee sample.
Significant leftward (red) and rightward (green) asymmetrical regions are those with a p≤0.05 after FWE correction. The T-statistic and p-value for all Davi130 labels can be found in Figure 6—source …
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Figure 6—source data 1
Complete Davi130 labels hemispheric asymmetry.
- https://cdn.elifesciences.org/articles/60136/elife-60136-fig6-data1-v2.docx
Figure 7
Workflow for creation of chimpanzee-specific shooting template and TPM, which can then be used in CAT12 structural preprocessing pipeline to create the Juna.Chimp template.
The resulting chimpanzee-shooting template, TPM and CAT atlas establishes the robust and reliable base to segment and spatially normalize the T1w images utilizing CAT12’s processing pipeline (Dahnke …
Tables
Key resources table
| Reagent type (species) or resource | Designation | Source or reference | Identifiers | Additional information |
|---|---|---|---|---|
| Software, algorithm | CAT12 | http://www.neuro.uni-jena.de/cat/ | RRID:SCR_019184 | |
| Software, algorithm | NCBR | http://www.chimpanzeebrain.org/ | RRID:SCR_019183 | |
| Software, algorithm | MATLAB | http://www.mathworks.com/products/matlab/ | RRID:SCR_001622 | |
| Software, algorithm | SPM | http://www.fil.ion.ucl.ac.uk/spm/ | RRID:SCR_007037 | |
| Software, algorithm | RStudio | http://www.rstudio.com/ | RRID:SCR_000432 | |
| Software, algorithm | 3D Slicer | http://slicer.org/ | RRID:SCR_005619 |
