Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum
- Instituto de Neurociencias CSIC-UMH, Spain
Abstract
Behavioural studies differentiate the rodent dorsal striatum (DS) into lateral and medial regions; however, anatomical evidence suggests that it is a unified structure. To understand striatal dynamics and basal ganglia functions, it is essential to clarify the circuitry that supports this behavioural-based segregation. Here, we show that the mouse DS is made of two non-overlapping functional circuits divided by a boundary. Combining in vivo optopatch-clamp and extracellular recordings of spontaneous and evoked sensory activity, we demonstrate different coupling of lateral and medial striatum to the cortex together with an independent integration of the spontaneous activity, due to particular corticostriatal connectivity and local attributes of each region. Additionally, we show differences in slow and fast oscillations and in the electrophysiological properties between striatonigral and striatopallidal neurons. In summary, these results demonstrate that the rodent DS is segregated in two neuronal circuits, in homology with the caudate and putamen nuclei of primates.
Data availability
All data generated during and/or analysed during the current study, as well as the required code to reproduce the figures, is available on the CSIC public repository. This is the URL access http://dx.doi.org/10.20350/digitalCSIC/13750.
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Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatumCSIC, 10.20350/digitalCSIC/13750.
Article and author information
Author details
Funding
Ministerio de Economía, Industria y Competitividad, Gobierno de España (BFU2014-60809-IN)
- Ramon Reig
Ministerio de Economía, Industria y Competitividad, Gobierno de España (SEV-2013-0317 and SEV-2017-0723)
- Ramon Reig
Ministerio de Economía, Industria y Competitividad, Gobierno de España (SEV2013-0317)
- María Sáez
Fundacion la Caixa (2016/00006/001)
- Roberto Montanari
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All the experimental procedures were conformed to the directive 2010/63/EU of the European Parliament and the RD 53/2013 Spanish regulation on the protection of animals use for scientific purposes, approved by the government of the Autonomous Community of Valencia, under the supervision of the Consejo Superior de Investigaciones Científicas and the Miguel Hernandez University Committee for Animal use in Laboratory.
Copyright
© 2021, Alegre-Cortés et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum
eLife 10:e60580.
https://doi.org/10.7554/eLife.60580
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