Convergence of cortical types and functional motifs in the human mesiotemporal lobe
- McGill University, Canada
- University of Western Ontario, Canada
- ETH Zurich, Switzerland
- Max Planck Institute Leipzig, Germany
- Monash University, Australia
- University of York, United Kingdom
Abstract
The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organization.
Data availability
Code and data related to this specific project are openly available under https://github.com/MICA-MNI/micaopen/tree/master/cortical_confluence, BigBrain related information are openly available under https://bigbrain.loris.ca/main.php. The human connectome project dataset is available under https://db.humanconnectome.org/.
Article and author information
Author details
Funding
Canadian HIV Trials Network, Canadian Institutes of Health Research (CIHR FDN-154298)
- Boris Bernhardt
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Morgan Barense, University of Toronto, Canada
Ethics
Human subjects: Participants gave informed consent and the study was approved by the local Research Ethics Board of the Montreal Neurological Institute and Hospital (2018-3469).
Version history
- Received: July 3, 2020
- Accepted: November 3, 2020
- Accepted Manuscript published: November 4, 2020 (version 1)
- Version of Record published: November 17, 2020 (version 2)
Copyright
© 2020, Paquola et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Convergence of cortical types and functional motifs in the human mesiotemporal lobe
eLife 9:e60673.
https://doi.org/10.7554/eLife.60673
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