How does regulatory focus alter attribute value construction (AVC) and evidence accumulation (EA)? We recorded EEG during food choices while participants responded naturally or regulated their choices by attending to health attributes or decreasing attention to taste attributes. Using a drift diffusion model, we predicted the time course of neural signals associated with AVC and EA. Results suggested that event-related-potentials (ERPs) correlated with the time course of model-predicted taste-attribute signals, with no modulation by regulation. By contrast, suppression of frontal and occipital alpha power correlated with the time course of EA, tracked tastiness according to its goal relevance, and predicted individual variation in successful down-regulation of tastiness. Additionally, an earlier rise in frontal and occipital theta power represented food tastiness more strongly during regulation, and predicted a weaker influence of food tastiness on behaviour. Our findings illuminate how regulation modifies the representation of attributes during the process of evidence accumulation.
Raw data are deposited on Open Science Framework, under the project DOI: 10.17605/OSF.IO/EWTVX .Raw Behavioural data: https://osf.io/yp2x9Raw EEG data: https://osf.io/p5wd2
EEG Dynamics of Self-Regulatory Strategies in Dietary Decision Making: EEG dataOpen Science Framework, p5wd2.
EEG Dynamics of Self-Regulatory Strategies in Dietary Decision Making: Behavioural dataOpen Science Framework, yp2x9.
- Cendri A Hutcherson
- Cendri A Hutcherson
- Cendri A Hutcherson
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Human subjects: All subjects gave written consent for data collection and publication prior to the experiment. The study was approved by the Research Ethics Board of the University of Toronto (Protocol #34322).
- Redmond G O'Connell, Trinity College Dublin, Ireland
© 2021, HajiHosseini & Hutcherson
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly involved in conditioned behavior, independent of secondary roles in the processing of external stimuli. Using fluorescent imaging, we found that cholinergic neurons are active during behavioral responding for a reward – even prior to reward delivery and in the absence of discrete stimuli. Photostimulation of basal forebrain cholinergic neurons, or their terminals in the basolateral amygdala (BLA), selectively promoted conditioned responding (licking), but not unconditioned behavior nor innate motor outputs. In vivo electrophysiological recordings during cholinergic photostimulation revealed reward-contingency-dependent suppression of BLA neural activity, but not prefrontal cortex. Finally, ex vivo experiments demonstrated that photostimulation of cholinergic terminals suppressed BLA projection neuron activity via monosynaptic muscarinic receptor signaling, while also facilitating firing in BLA GABAergic interneurons. Taken together, we show that the neural and behavioral effects of basal forebrain cholinergic activation are modulated by reward contingency in a target-specific manner.
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