Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
- University of Oxford, United Kingdom
Abstract
Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here we develop an approach that allows us to recover similar trajectories on a millisecond timescale in non-invasive human recordings. We selectively suppress activity related to three task-axes, relevant and irrelevant sensory inputs and response direction in magnetoencephalography data acquired during context-dependent choices. Recordings from premotor cortex show a progression from processing sensory input to processing the response. In contrast to previous macaque recordings, information related to choice-irrelevant features is represented more weakly than choice-relevant sensory information. To test whether this mechanistic difference between species is caused by extensive overtraining common in non-human primate studies, we trained humans on >20,000 trials of the task. Choice-irrelevant features were still weaker than relevant features in premotor cortex after overtraining.
Data availability
Source data files for figures 2, 3, 4, and are provided.All datasets and codes for reproducing the results will be uploaded to Open Science Framework (OSF) after acceptance.
Article and author information
Author details
Laurence Tudor Hunt
Miriam C Klein-Flügge
Funding
Japan Society for the Promotion of Science (23118001,23118002)
- Yu Takagi
Uehara Memorial Foundation
- Yu Takagi
Sir Henry Wellcome Fellowship (103184/Z/13/Z)
- Miriam C Klein-Flügge
Wellcome Senior Research Fellowship (104765/Z/14/Z)
- Timothy E Behrens
Wellcome Principal Research Fellowship (219525/Z/19/Z)
- Timothy E Behrens
JS McDonnell Foundation award (JSMF220020372)
- Timothy E Behrens
Wellcome Collaborator award (214314/Z/18/Z)
- Timothy E Behrens
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: The study was approved by the University College London (UCL) Research Ethics Committee (reference 1825/005) and all participants gave written informed consent.
Copyright
© 2021, Takagi et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
eLife 10:e60988.
https://doi.org/10.7554/eLife.60988
