Sense of coherence and risk of breast cancer
- Karolinska Institutet, Sweden
Abstract
Sense of coherence (SoC) is the origin of health according to Antonovsky. The link between SoC and risk of cancer has however rarely been assessed. We performed a cohort study of 46,436 women from the Karolinska Mammography Project for Risk Prediction of Breast Cancer (Karma). Participants answered a SoC-13 questionnaire at recruitment to Karma and were subsequently followed up for incident breast cancer. Multivariate Cox models were used to assess the hazard ratios (HRs) of breast cancer in relation to SoC. We identified 771 incident cases of breast cancer during follow-up (median time: 5.2 years). No association was found between SoC, either as a categorical (strong vs. weak SoC, HR: 1.08, 95% CI: 0.90-1.29) or continuous (HR: 1.08; 95% CI: 1.00-1.17 per standard deviation increase of SoC) variable, and risk of breast cancer. In summary, we found little evidence to support an association between SoC and risk of breast cancer.
Data availability
The datasets analysed during the present study can be shared and are available from the corresponding author on reasonable request. More information regarding the data access to KARMA can be found at: [https://karmastudy.org/contact/data-access/]. The data are not publicly available due to Swedish laws.
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Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA)karmastudy.org, doi: 10.1093/ije/dyw357.
Article and author information
Author details
Funding
Cancerfonden (CAN 2017/322)
- Fang Fang
Swedish Research Council for Health, Working Life, and Welfare (2017-00531)
- Fang Fang
Karolinska Institutet (Karolinska Institutet Senior Researcher Award)
- Fang Fang
Karolinska Institutet (Strategic Research Area in Epidemiology Award)
- Fang Fang
China Scholarship Council (201806240005)
- Kejia Hu
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Approval was granted by the Regional Ethics Review Board in Stockholm, Sweden (Dnr 2010/958-31/1). Informed consent was obtained from all individual participants included in the study.
Copyright
© 2020, Hu et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Sense of coherence and risk of breast cancer
eLife 9:e61469.
https://doi.org/10.7554/eLife.61469
