Increased influence of prior choices on perceptual decisions in autism
- Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Israel
- The Autism Center/ALUT, Shamir Medical Center, Israel
- Sackler Faculty of Medicine, Tel Aviv University, Israel
Figures
Figure 1
Location discrimination – event sequence within and across trials.
All stimuli (filled circles) were discriminated according to location, that is, whether the circle lay to the left or to the right of the screen center (2AFC). Each trial comprised a series of …
Figure 2 with 1 supplement
Location discrimination – psychometric function shifts.
(A) Psychometric curves for an example participant with ASD (left plot) and an example control participant (right plot) performing location discrimination. The psychometric curves represent the …
Figure 2—figure supplement 1
Test stimulus convergence for the location discrimination experiment, primary condition.
Magnitude (absolute value) of the ‘test’ circle location as a function of trial number. Red and blue lines (bands) represent mean stimulus location (± SEM) for the ASD and control participants, …
Figure 3
Perceptual decision model schematic.
Perceptual choices were modeled using a logistic regression with four factors (providing their respective fitted beta coefficients): (i) the current stimulus (βcurr_stimulus), (ii) previous stimuli …
Figure 4 with 2 supplements
Location discrimination (primary condition) – model parameters.
Beta coefficients for model parameters: current stimulus, previous choices and previous stimuli (left, center, and right plots, respectively). Red and blue bars represent the values (mean ± SEM) for …
Figure 4—figure supplement 1
Location discrimination (primary condition) – five choices back model parameters.
Current stimulus (A) and previous choices (B) beta coefficients (mean ± SEM) for the ASD (red) and control (blue) participants. The prior choice at t-1 immediately precedes the current choice (at t).…
Figure 4—figure supplement 2
Scatter of βprev_choices coefficients (primary condition) vs. ADOS scores.
Each data point represents one ASD participant.
Figure 5 with 1 supplement
Heading discrimination – psychometric function shifts.
(A) Psychometric curves for an example participant with ASD (left plot) and an example control participant (right plot) performing heading discrimination (visual condition, with 50% coherence). The …
Figure 5—figure supplement 1
Stimulus convergence for the heading discrimination experiment.
Stimulus heading direction (absolute value) as a function of trial number for (A) vestibular and (B) visual trials (with different coherence levels). Red and blue lines (bands) represent the mean (± …
Figure 6
Heading discrimination – model parameters.
Beta coefficients for three model parameters: current stimulus, previous choice and previous stimulus (left, center, and right plots, respectively). These were averaged over three stimulus …
Figure 7 with 2 supplements
Results for the Response Invariant location discrimination condition.
(A) PSE shifts (ΔPSE = PSE for left biased priors minus PSE for right biased prior). Red and blue bars represent ΔPSEs (mean ± SEM) for participants with ASD and controls, respectively. (B) Beta …
Figure 7—figure supplement 1
Test stimulus convergence for the location discrimination experiment, Response Invariant condition.
Magnitude (absolute value) of the ‘test’ circle location as a function of trial number. Red and blue lines (bands) represent mean stimulus location (± SEM) for the ASD and control participants, …
Figure 7—figure supplement 2
Scatter of βprev_choices coefficients (Response Invariant condition) vs. ADOS scores.
Each data point represents one ASD participant. The dashed line marks y = 0.
Tables
Table 1
ASD participant details.
| ASD participant number | Age | SCQ | IQ – WISC IV | ADOS | ADI-R | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Block-Design | Matrix-Reasoning | Vocabulary | Similarities | Calibrated Severity Score | Social Affect | RRB | Reciprocal Social Interaction | Communication | RRB | |||
| 1 | 8 | 17 | 7 | 9 | 10 | 9 | 9 | 7 | 7 | 13 | 11 | 5 |
| 2 | 9 | 17 | 11 | 9 | 9 | 8 | 9 | 10 | 10 | 27 | 14 | 6 |
| 3 | 10 | 21 | 13 | 16 | 13 | 13 | 8 | 8 | 8 | 10 | 13 | 1 |
| 4 | 10 | 14 | 12 | 13 | 10 | 16 | 9 | 9 | 9 | 11 | 8 | 5 |
| 5 | 10 | 11 | 9 | 7 | 7 | 7 | 9 | 9 | 9 | 12 | 12 | 2 |
| 6 | 11 | 21 | 11 | 10 | 7 | 10 | 8 | 7 | 7 | 13 | 15 | 10 |
| 7 | 11 | 15 | 7 | 11 | 8 | 7 | 8 | 8 | 8 | 11 | 11 | 5 |
| 8 | 11 | 19 | 12 | 13 | 10 | 16 | 7 | 7 | 7 | 17 | 13 | 5 |
| 9 | 11 | 22 | 12 | 9 | 11 | 10 | 7 | 10 | 10 | 23 | 19 | 7 |
| 10 | 12 | 13 | 15 | 13 | 12 | 10 | 9 | 8 | 8 | 11 | 8 | 3 |
| 11 | 12 | 29 | 10 | 12 | 7 | 8 | 7 | 7 | 7 | 20 | 19 | 4 |
| 12 | 13 | 22 | 8 | 7 | 11 | 8 | 10 | 10 | 10 | 14 | 9 | 9 |
| 13 | 13 | 12 | 7 | 10 | 8 | 10 | 10 | 9 | 9 | 23 | 11 | 4 |
| 14 | 14 | 19 | 15 | 9 | 15 | 17 | 10 | 9 | 9 | 20 | 14 | 8 |
| 15 | 14 | 14 | 14 | 9 | 12 | 15 | 7 | 5 | 5 | 11 | 7 | 5 |
| 16 | 15 | 18 | 7 | 9 | 10 | 9 | 6 | 6 | 6 | 8 | 4 | 5 |
| 17 | 16 | 30 | 13 | 9 | 11 | 12 | 8 | 6 | 6 | 13 | 13 | 8 |
| 18 | 17 | 22 | 9 | 11 | 8 | 10 | 10 | 10 | 10 | 11 | 5 | 6 |
| Mean ± SD | 12.1 ± 2.4 | 18.7 ± 5.3 | 10.7 ± 2.8 | 10.3 ± 2.3 | 9.9 ± 2.2 | 10.8 ± 3.2 | 8.4 ± 1.2 | 8.1 ± 1.6 | 8.1 ± 1.6 | 14.9 ± 5.4 | 11.4 ± 4.2 | 5.4 ± 2.3 |
-
SCQ scores are current from the time of the study. Other scores are from within 0–5 years of the study. RRB - Restricted and Repetitive Behaviors.
Table 2
Control participant details.
| Control participant number | Age | SCQ | IQ – WISC IV | |||
|---|---|---|---|---|---|---|
| Block-Design | Matrix-Reasoning | Vocabulary | Similarities | |||
| 1 | 8 | 5 | 14 | 10 | 18 | 12 |
| 2 | 9 | 1 | 14 | 10 | 15 | 10 |
| 3 | 9 | 1 | 13 | 13 | 17 | 14 |
| 4 | 9 | 1 | 13 | 14 | 14 | 15 |
| 5 | 10 | 1 | 11 | 10 | 10 | 12 |
| 6 | 11 | 1 | 9 | 15 | 15 | 8 |
| 7 | 11 | 3 | 10 | 8 | 9 | 10 |
| 8 | 12 | 10 | 6 | 11 | 10 | 9 |
| 9 | 12 | 1 | 12 | 7 | 8 | 9 |
| 10 | 12 | 1 | 9 | 8 | 11 | 9 |
| 11 | 13 | 3 | 14 | 12 | 13 | 18 |
| 12 | 13 | 0 | 5 | 8 | 8 | 9 |
| 13 | 13 | 8 | 14 | 17 | 11 | 16 |
| 14 | 14 | 3 | 10 | 15 | 8 | 13 |
| 15 | 15 | 0 | 10 | 14 | 12 | 13 |
| 16 | 15 | 5 | 12 | 16 | 9 | 7 |
| 17 | 15 | 7 | 13 | 16 | 12 | 15 |
| 18 | 16 | 2 | 14 | 14 | 8 | 11 |
| 19 | 16 | 3 | 8 | 8 | 9 | 9 |
| 20 | 16 | 2 | 11 | 10 | 5 | 11 |
| Mean ± SD | 12.5 ± 2.6 | 2.9 ± 2.8 | 11.1 ± 2.7 | 11.8 ± 3.2 | 11.1 ± 3.4 | 11.5 ± 3.0 |
-
IQ and SCQ scores are current from the time of the study.
