The relationship between AD pathology and cognitive decline is an important topic in the aging research field. Recent studies suggest that memory deficits are more susceptible to phosphorylated tau (Ptau), than amyloid-beta. However, little is known regarding the neurocognitive mechanisms linking Ptau and memory related decline. Here, we extracted data from ADNI participants with CSF (cerebrospinal fluid) Ptau collected at baseline, diffusion tensor imaging measure twice, two-year apart, and longitudinal memory data over five years. We defined three age- and education-matched groups: Ptau negative cognitively unimpaired, Ptau positive cognitively unimpaired, and Ptau positive individuals with mild cognitive impairment. We found the presence of CSF Ptau at baseline was related to a loss of structural stability in medial temporal lobe connectivity in a way that matched proposed disease progression, and this loss of stability in connections known to be important for memory moderated the relationship between Ptau accumulation and memory decline.
Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
- Feng V Lin
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Human subjects: Human subjects: The current study is a secondary data analysis of limited-identified data per data user agreement between ADNI and F.L.. The human subject research of original ADNI data collection was conducted at each ADNI data collection site (see the full list of sites http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf); and written informed consent was obtained from each participant (see http://adni.loni.usc.edu/wp-content/uploads/2008/07/adni2-procedures-manual.pdf for detailed information about ethical procedures for ADNI). Protocol_11.19.14
- Muireann Irish, University of Sydney, Australia
© 2020, Chen et al.
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