Shown are the results of a toxicology panel comprising the relative plasma levels of liver enzymes (A) ALT, (B) AST, and (C) ALP, as well as the relative plasma levels of free triiodothyronine (T3; D). For the liver enzymes, values are shown for male mice fed for 16 weeks with either the control diet (CF) or a diet containing sodium selenite (CF-SS). Free T3 levels were assessed in the same animals fed the indicated diets for 25 weeks. Bars denote SEM. Statistically significant differences (as compared with the corresponding CF values) are indicated (***p<0.001). For selenium-supplemented animals, the plasma levels of ALT, AST, ALP, and free T3 are either the same as those of control-fed littermates (AST, ALP, and free T3), or lower (ALT), indicating that the sodium selenite-containing diet is not toxic to mice. N ≥ 8 for all groups.