Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements
- Tübingen University, Germany
Abstract
At any moment in time, new information is sampled from the environment and interacts with ongoing brain state. Often, such interaction takes place within individual circuits that are capable of both mediating the internally ongoing plan as well as representing exogenous sensory events. Here we investigated how sensory-driven neural activity can be integrated, very often in the same neuron types, into ongoing saccade motor commands. Despite the ballistic nature of saccades, visually-induced action potentials in the rhesus macaque superior colliculus (SC), a structure known to drive eye movements, not only occurred intra-saccadically, but they were also associated with highly predictable modifications of ongoing eye movements. Such predictable modifications reflected a simultaneity of movement-related discharge at one SC site and visually-induced activity at another. Our results suggest instantaneous readout of the SC during movement generation, irrespective of activity source, and they explain a significant component of kinematic variability of motor outputs.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files. Source data files have been provided for all figures.
Article and author information
Author details
Funding
Deutsche Forschungsgemeinschaft (FOR1847 (project A6: HA6749/2-1))
- Antimo Buonocore
- Ziad M Hafed
Deutsche Forschungsgemeinschaft (DFG EXC307)
- Antimo Buonocore
- Ziad M Hafed
Deutsche Forschungsgemeinschaft (SFB1233; TP 11; project number 276693517)
- Fatemeh Khademi
- Ziad M Hafed
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: The experiments were approved (licenses: CIN3/13; CIN4/19G) by ethics committees at the regional governmental offices of the city of Tuebingen and were in accordance with European Union guidelines on animal research and the associated implementations of these guidelines in German law.
Copyright
© 2021, Buonocore et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements
eLife 10:e64150.
https://doi.org/10.7554/eLife.64150
