Only eCpGs with reliable measurements (ICC >0.4) were considered (Sugden et al., 2020). eCpGs were classified in all (grey), inverse (yellow), and positive (green). The y-axis represents the odds ratio (OR) of the enrichment. In all cases, the enrichment was computed against non eCpGs. (A) Enrichment for CpG island relative positions: CpG island, N- and S-shore, N- and S-shelf, and open sea. (B) Enrichment for ROADMAP blood chromatin states (Roadmap Epigenomics Consortium et al., 2015): active TSS (TssA), flanking active TSS (TssAFlnk), transcription at 5’ and 3’ (TxFlnk), transcription region (Tx), weak transcription region (TxWk), enhancer (Enh); genic enhancer (EnhG), zinc finger genes and repeats (ZNF.Rpts), flanking bivalent region (BivFlnx), bivalent enhancer (EnhBiv), bivalent TSS (TssBiv), heterochromatin (Het), repressed Polycomb (ReprPC), weak repressed Polycomb (ReprPCWk), and quiescent region (Quies). Chromatin states can be grouped in active transcription start site proximal promoter states (TssProxProm), active transcribed states (ActTrans), enhancers (Enhancers), bivalent regulatory states (BivReg) and repressed Polycomb states (ReprPoly). (C) Enrichment for groups of CpGs with different median methylation levels: low (0–0.3), medium (0.3–0.7), and high (0.7–1) (Huse et al., 2015).