1. Computational and Systems Biology
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Cardiac Optogenetics: A move in the light direction

  1. Eike M Wülfers
  2. Franziska Schneider-Warme  Is a corresponding author
  1. Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg – Bad Krozingen, Germany
  2. Faculty of Medicine, University of Freiburg, Germany
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Cite this article as: eLife 2021;10:e65360 doi: 10.7554/eLife.65360
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Figures

Optogenetic control of spiral waves.

(A) Under certain conditions in the heart, spiral waves of electrical excitation are emitted by a ‘rotor’ of self-sustained electrical excitation. Hussaini et al. have used computer simulations to explore how a rotor in a two-dimensional model of heart tissue responds to various patterns of low-intensity illumination. (B) Upon illumination with a spatial gradient (here, the intensity increases from left to right), the rotor moves in the direction of higher light intensity. (C) Partial illumination of the model tissue with constant sub-threshold intensity light also causes the rotor to move towards the illuminated area.

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